Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | AZD8055 | 1 | 72 | 1.0 | 1711.5 | 3237.8 | 1279.8 | 0.0 | 0.242 | 0.529 | 1.339 | HCC70 AZD8055 0 1 72 |
| HCC70 | AZD8055 | 1 | 72 | 3.2 | 1771.0 | 3237.8 | 1279.8 | 0.505 | 0.275 | 0.547 | 1.339 | HCC70 AZD8055 0 1 72 |
| HCC70 | Dactolisib | 1 | 72 | 0.001 | 2962.3 | 3377.8 | 1279.8 | -3.0 | 0.821 | 0.877 | 1.400 | HCC70 BEZ235 0 1 72 |
| HCC70 | Dactolisib | 1 | 72 | 0.0032 | 2962.0 | 3377.8 | 1279.8 | -2.49 | 0.821 | 0.877 | 1.400 | HCC70 BEZ235 0 1 72 |
| HCC70 | Dactolisib | 1 | 72 | 0.01 | 2560.5 | 3377.8 | 1279.8 | -2.0 | 0.641 | 0.758 | 1.400 | HCC70 BEZ235 0 1 72 |
| HCC70 | Dactolisib | 1 | 72 | 0.032 | 2354.5 | 3377.8 | 1279.8 | -1.49 | 0.546 | 0.697 | 1.400 | HCC70 BEZ235 0 1 72 |
| HCC70 | Dactolisib | 1 | 72 | 0.1 | 2185.0 | 3377.8 | 1279.8 | -1.0 | 0.465 | 0.647 | 1.400 | HCC70 BEZ235 0 1 72 |
| HCC70 | Dactolisib | 1 | 72 | 0.32 | 2085.3 | 3377.8 | 1279.8 | -0.495 | 0.417 | 0.617 | 1.400 | HCC70 BEZ235 0 1 72 |
| HCC70 | Dactolisib | 1 | 72 | 1.0 | 1707.3 | 3377.8 | 1279.8 | 0.0 | 0.229 | 0.505 | 1.400 | HCC70 BEZ235 0 1 72 |
| HCC70 | Dactolisib | 1 | 72 | 3.2 | 1162.0 | 3377.8 | 1279.8 | 0.505 | -0.067 | 0.344 | 1.400 | HCC70 BEZ235 0 1 72 |
| HCC70 | Buparlisib | 1 | 72 | 0.001 | 3514.0 | 3318.0 | 1279.8 | -3.0 | 1.090 | 1.060 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC70 | Buparlisib | 1 | 72 | 0.0032 | 3270.3 | 3318.0 | 1279.8 | -2.49 | 0.979 | 0.986 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC70 | Buparlisib | 1 | 72 | 0.01 | 3367.3 | 3318.0 | 1279.8 | -2.0 | 1.020 | 1.010 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC70 | Buparlisib | 1 | 72 | 0.032 | 3663.5 | 3318.0 | 1279.8 | -1.49 | 1.150 | 1.100 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC70 | Buparlisib | 1 | 72 | 0.1 | 3363.3 | 3318.0 | 1279.8 | -1.0 | 1.020 | 1.010 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC70 | Buparlisib | 1 | 72 | 0.32 | 2629.0 | 3318.0 | 1279.8 | -0.495 | 0.688 | 0.792 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC70 | Buparlisib | 1 | 72 | 1.0 | 1703.0 | 3318.0 | 1279.8 | 0.0 | 0.231 | 0.513 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC70 | Buparlisib | 1 | 72 | 3.2 | 501.8 | 3318.0 | 1279.8 | 0.505 | -0.494 | 0.151 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC70 | BX-912 | 1 | 72 | 0.001 | 3458.3 | 3461.8 | 1279.8 | -3.0 | 0.999 | 0.999 | 1.436 | HCC70 BX912 0 1 72 |
| HCC70 | BX-912 | 1 | 72 | 0.0032 | 3323.8 | 3461.8 | 1279.8 | -2.49 | 0.944 | 0.960 | 1.436 | HCC70 BX912 0 1 72 |
| HCC70 | BX-912 | 1 | 72 | 0.01 | 3606.5 | 3461.8 | 1279.8 | -2.0 | 1.060 | 1.040 | 1.436 | HCC70 BX912 0 1 72 |
| HCC70 | BX-912 | 1 | 72 | 0.032 | 3679.5 | 3461.8 | 1279.8 | -1.49 | 1.090 | 1.060 | 1.436 | HCC70 BX912 0 1 72 |
| HCC70 | BX-912 | 1 | 72 | 0.1 | 3498.3 | 3461.8 | 1279.8 | -1.0 | 1.010 | 1.010 | 1.436 | HCC70 BX912 0 1 72 |
| HCC70 | BX-912 | 1 | 72 | 0.32 | 3442.0 | 3461.8 | 1279.8 | -0.495 | 0.992 | 0.994 | 1.436 | HCC70 BX912 0 1 72 |
| HCC70 | BX-912 | 1 | 72 | 1.0 | 2480.5 | 3461.8 | 1279.8 | 0.0 | 0.586 | 0.717 | 1.436 | HCC70 BX912 0 1 72 |