Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TGX221 | 3 | 72 | 0.032 | 3179.5 | 3303.0 | 1180.5 | -1.49 | 0.949 | 0.963 | 1.484 | HCC38 TGX221 0 3 72 |
| HCC38 | TGX221 | 3 | 72 | 0.1 | 3139.3 | 3303.0 | 1180.5 | -1.0 | 0.933 | 0.950 | 1.484 | HCC38 TGX221 0 3 72 |
| HCC38 | TGX221 | 3 | 72 | 0.32 | 3051.8 | 3303.0 | 1180.5 | -0.495 | 0.896 | 0.924 | 1.484 | HCC38 TGX221 0 3 72 |
| HCC38 | TGX221 | 3 | 72 | 1.0 | 3050.3 | 3303.0 | 1180.5 | 0.0 | 0.896 | 0.923 | 1.484 | HCC38 TGX221 0 3 72 |
| HCC38 | TGX221 | 3 | 72 | 3.2 | 2859.8 | 3303.0 | 1180.5 | 0.505 | 0.815 | 0.866 | 1.484 | HCC38 TGX221 0 3 72 |
| HCC38 | Torin1 | 3 | 72 | 0.001 | 2979.8 | 3204.3 | 1180.5 | -3.0 | 0.902 | 0.930 | 1.441 | HCC38 Torin1 0 3 72 |
| HCC38 | Torin1 | 3 | 72 | 0.0032 | 2820.5 | 3204.3 | 1180.5 | -2.49 | 0.831 | 0.880 | 1.441 | HCC38 Torin1 0 3 72 |
| HCC38 | Torin1 | 3 | 72 | 0.01 | 2478.8 | 3204.3 | 1180.5 | -2.0 | 0.674 | 0.774 | 1.441 | HCC38 Torin1 0 3 72 |
| HCC38 | Torin1 | 3 | 72 | 0.032 | 1952.3 | 3204.3 | 1180.5 | -1.49 | 0.418 | 0.609 | 1.441 | HCC38 Torin1 0 3 72 |
| HCC38 | Torin1 | 3 | 72 | 0.1 | 1495.0 | 3204.3 | 1180.5 | -1.0 | 0.178 | 0.467 | 1.441 | HCC38 Torin1 0 3 72 |
| HCC38 | Torin1 | 3 | 72 | 0.32 | 1196.8 | 3204.3 | 1180.5 | -0.495 | 0.010 | 0.373 | 1.441 | HCC38 Torin1 0 3 72 |
| HCC38 | Torin1 | 3 | 72 | 1.0 | 980.5 | 3204.3 | 1180.5 | 0.0 | -0.121 | 0.306 | 1.441 | HCC38 Torin1 0 3 72 |
| HCC38 | Torin1 | 3 | 72 | 3.2 | 853.0 | 3204.3 | 1180.5 | 0.505 | -0.202 | 0.266 | 1.441 | HCC38 Torin1 0 3 72 |
| HCC38 | Torin2 | 3 | 72 | 0.001 | 2908.5 | 3083.5 | 1180.5 | -3.0 | 0.917 | 0.943 | 1.385 | HCC38 Torin2 0 3 72 |
| HCC38 | Torin2 | 3 | 72 | 0.0032 | 2572.8 | 3083.5 | 1180.5 | -2.49 | 0.755 | 0.834 | 1.385 | HCC38 Torin2 0 3 72 |
| HCC38 | Torin2 | 3 | 72 | 0.01 | 2168.0 | 3083.5 | 1180.5 | -2.0 | 0.551 | 0.703 | 1.385 | HCC38 Torin2 0 3 72 |
| HCC38 | Torin2 | 3 | 72 | 0.032 | 1598.8 | 3083.5 | 1180.5 | -1.49 | 0.245 | 0.518 | 1.385 | HCC38 Torin2 0 3 72 |
| HCC38 | Torin2 | 3 | 72 | 0.1 | 1155.5 | 3083.5 | 1180.5 | -1.0 | -0.015 | 0.375 | 1.385 | HCC38 Torin2 0 3 72 |
| HCC38 | Torin2 | 3 | 72 | 0.32 | 791.8 | 3083.5 | 1180.5 | -0.495 | -0.251 | 0.257 | 1.385 | HCC38 Torin2 0 3 72 |
| HCC38 | Torin2 | 3 | 72 | 1.0 | 563.3 | 3083.5 | 1180.5 | 0.0 | -0.414 | 0.183 | 1.385 | HCC38 Torin2 0 3 72 |
| HCC38 | Torin2 | 3 | 72 | 3.2 | 304.0 | 3083.5 | 1180.5 | 0.505 | -0.624 | 0.099 | 1.385 | HCC38 Torin2 0 3 72 |
| HCC38 | Trametinib | 3 | 72 | 0.001 | 3117.0 | 3307.5 | 1180.5 | -3.0 | 0.922 | 0.942 | 1.486 | HCC38 Trametinib 0 3 72 |
| HCC38 | Trametinib | 3 | 72 | 0.0032 | 3008.8 | 3307.5 | 1180.5 | -2.49 | 0.877 | 0.910 | 1.486 | HCC38 Trametinib 0 3 72 |
| HCC38 | Trametinib | 3 | 72 | 0.01 | 3140.5 | 3307.5 | 1180.5 | -2.0 | 0.931 | 0.950 | 1.486 | HCC38 Trametinib 0 3 72 |
| HCC38 | Trametinib | 3 | 72 | 0.032 | 3093.3 | 3307.5 | 1180.5 | -1.49 | 0.912 | 0.935 | 1.486 | HCC38 Trametinib 0 3 72 |