Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | AZD-6482 | 3 | 72 | 3.2 | 2715.8 | 3938.5 | 1175.8 | 0.505 | 0.616 | 0.690 | 1.744 | BT549 AZD6482 0 3 72 |
| BT-549 | AZD8055 | 3 | 72 | 0.001 | 3552.5 | 3973.3 | 1175.8 | -3.0 | 0.877 | 0.894 | 1.757 | BT549 AZD8055 0 3 72 |
| BT-549 | AZD8055 | 3 | 72 | 0.0032 | 3194.0 | 3973.3 | 1175.8 | -2.49 | 0.766 | 0.804 | 1.757 | BT549 AZD8055 0 3 72 |
| BT-549 | AZD8055 | 3 | 72 | 0.01 | 2854.0 | 3973.3 | 1175.8 | -2.0 | 0.657 | 0.718 | 1.757 | BT549 AZD8055 0 3 72 |
| BT-549 | AZD8055 | 3 | 72 | 0.032 | 2241.0 | 3973.3 | 1175.8 | -1.49 | 0.444 | 0.564 | 1.757 | BT549 AZD8055 0 3 72 |
| BT-549 | AZD8055 | 3 | 72 | 0.1 | 1622.3 | 3973.3 | 1175.8 | -1.0 | 0.201 | 0.408 | 1.757 | BT549 AZD8055 0 3 72 |
| BT-549 | AZD8055 | 3 | 72 | 0.32 | 1330.5 | 3973.3 | 1175.8 | -0.495 | 0.073 | 0.335 | 1.757 | BT549 AZD8055 0 3 72 |
| BT-549 | AZD8055 | 3 | 72 | 1.0 | 1522.8 | 3973.3 | 1175.8 | 0.0 | 0.159 | 0.383 | 1.757 | BT549 AZD8055 0 3 72 |
| BT-549 | AZD8055 | 3 | 72 | 3.2 | 1782.3 | 3973.3 | 1175.8 | 0.505 | 0.267 | 0.449 | 1.757 | BT549 AZD8055 0 3 72 |
| BT-549 | Dactolisib | 3 | 72 | 0.001 | 3471.3 | 4098.5 | 1175.8 | -3.0 | 0.824 | 0.847 | 1.801 | BT549 BEZ235 0 3 72 |
| BT-549 | Dactolisib | 3 | 72 | 0.0032 | 2896.0 | 4098.5 | 1175.8 | -2.49 | 0.649 | 0.707 | 1.801 | BT549 BEZ235 0 3 72 |
| BT-549 | Dactolisib | 3 | 72 | 0.01 | 1995.3 | 4098.5 | 1175.8 | -2.0 | 0.341 | 0.487 | 1.801 | BT549 BEZ235 0 3 72 |
| BT-549 | Dactolisib | 3 | 72 | 0.032 | 1630.3 | 4098.5 | 1175.8 | -1.49 | 0.199 | 0.398 | 1.801 | BT549 BEZ235 0 3 72 |
| BT-549 | Dactolisib | 3 | 72 | 0.1 | 1421.3 | 4098.5 | 1175.8 | -1.0 | 0.111 | 0.347 | 1.801 | BT549 BEZ235 0 3 72 |
| BT-549 | Dactolisib | 3 | 72 | 0.32 | 1263.8 | 4098.5 | 1175.8 | -0.495 | 0.041 | 0.308 | 1.801 | BT549 BEZ235 0 3 72 |
| BT-549 | Dactolisib | 3 | 72 | 1.0 | 1156.3 | 4098.5 | 1175.8 | 0.0 | -0.009 | 0.282 | 1.801 | BT549 BEZ235 0 3 72 |
| BT-549 | Dactolisib | 3 | 72 | 3.2 | 1161.8 | 4098.5 | 1175.8 | 0.505 | -0.007 | 0.283 | 1.801 | BT549 BEZ235 0 3 72 |
| BT-549 | Buparlisib | 3 | 72 | 0.001 | 3863.5 | 4081.3 | 1175.8 | -3.0 | 0.940 | 0.947 | 1.795 | BT549 BKM120 0 3 72 |
| BT-549 | Buparlisib | 3 | 72 | 0.0032 | 3632.8 | 4081.3 | 1175.8 | -2.49 | 0.874 | 0.890 | 1.795 | BT549 BKM120 0 3 72 |
| BT-549 | Buparlisib | 3 | 72 | 0.01 | 3826.8 | 4081.3 | 1175.8 | -2.0 | 0.930 | 0.938 | 1.795 | BT549 BKM120 0 3 72 |
| BT-549 | Buparlisib | 3 | 72 | 0.032 | 3887.3 | 4081.3 | 1175.8 | -1.49 | 0.946 | 0.952 | 1.795 | BT549 BKM120 0 3 72 |
| BT-549 | Buparlisib | 3 | 72 | 0.1 | 3685.8 | 4081.3 | 1175.8 | -1.0 | 0.890 | 0.903 | 1.795 | BT549 BKM120 0 3 72 |
| BT-549 | Buparlisib | 3 | 72 | 0.32 | 3206.8 | 4081.3 | 1175.8 | -0.495 | 0.749 | 0.786 | 1.795 | BT549 BKM120 0 3 72 |
| BT-549 | Buparlisib | 3 | 72 | 1.0 | 1769.8 | 4081.3 | 1175.8 | 0.0 | 0.256 | 0.434 | 1.795 | BT549 BKM120 0 3 72 |
| BT-549 | Buparlisib | 3 | 72 | 3.2 | 540.8 | 4081.3 | 1175.8 | 0.505 | -0.351 | 0.132 | 1.795 | BT549 BKM120 0 3 72 |