Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-549 GDC-0980 2 72
0.01
 4451.8 4792.0 1249.6
-2.0
 0.925 0.929 1.939
BT549 GDC0980 0 2 72
BT-549 GDC-0980 2 72
0.032
 4257.3 4792.0 1249.6
-1.49
 0.882 0.888 1.939
BT549 GDC0980 0 2 72
BT-549 GDC-0980 2 72
0.1
 3362.3 4792.0 1249.6
-1.0
 0.666 0.702 1.939
BT549 GDC0980 0 2 72
BT-549 GDC-0980 2 72
0.32
 2205.5 4792.0 1249.6
-0.495
 0.340 0.460 1.939
BT549 GDC0980 0 2 72
BT-549 GDC-0980 2 72
1.0
 1709.5 4792.0 1249.6
0.0
 0.175 0.357 1.939
BT549 GDC0980 0 2 72
BT-549 GDC-0980 2 72
3.2
 1314.3 4792.0 1249.6
0.505
 0.026 0.274 1.939
BT549 GDC0980 0 2 72
BT-549 Omipalisib 2 72
0.001
 3670.5 4963.8 1249.6
-3.0
 0.719 0.739 1.990
BT549 GSK458 0 2 72
BT-549 Omipalisib 2 72
0.0032
 4043.5 4963.8 1249.6
-2.49
 0.804 0.815 1.990
BT549 GSK458 0 2 72
BT-549 Omipalisib 2 72
0.01
 2795.3 4963.8 1249.6
-2.0
 0.499 0.563 1.990
BT549 GSK458 0 2 72
BT-549 Omipalisib 2 72
0.032
 1971.5 4963.8 1249.6
-1.49
 0.258 0.397 1.990
BT549 GSK458 0 2 72
BT-549 Omipalisib 2 72
0.1
 1429.3 4963.8 1249.6
-1.0
 0.070 0.288 1.990
BT549 GSK458 0 2 72
BT-549 Omipalisib 2 72
0.32
 1214.0 4963.8 1249.6
-0.495
 -0.014 0.245 1.990
BT549 GSK458 0 2 72
BT-549 Omipalisib 2 72
1.0
 1045.3 4963.8 1249.6
0.0
 -0.086 0.211 1.990
BT549 GSK458 0 2 72
BT-549 Omipalisib 2 72
3.2
 630.0 4963.8 1249.6
0.505
 -0.291 0.127 1.990
BT549 GSK458 0 2 72
BT-549 KIN001-244 2 72
0.001
 4702.8 4727.5 1249.6
-3.0
 0.995 0.995 1.920
BT549 KIN001-244 0 2 72
BT-549 KIN001-244 2 72
0.0032
 4779.8 4727.5 1249.6
-2.49
 1.010 1.010 1.920
BT549 KIN001-244 0 2 72
BT-549 KIN001-244 2 72
0.01
 4625.5 4727.5 1249.6
-2.0
 0.977 0.978 1.920
BT549 KIN001-244 0 2 72
BT-549 KIN001-244 2 72
0.032
 4914.8 4727.5 1249.6
-1.49
 1.040 1.040 1.920
BT549 KIN001-244 0 2 72
BT-549 KIN001-244 2 72
0.1
 4945.8 4727.5 1249.6
-1.0
 1.050 1.050 1.920
BT549 KIN001-244 0 2 72
BT-549 KIN001-244 2 72
0.32
 4618.5 4727.5 1249.6
-0.495
 0.976 0.977 1.920
BT549 KIN001-244 0 2 72
BT-549 KIN001-244 2 72
1.0
 4590.5 4727.5 1249.6
0.0
 0.970 0.971 1.920
BT549 KIN001-244 0 2 72
BT-549 KIN001-244 2 72
3.2
 4208.3 4727.5 1249.6
0.505
 0.882 0.890 1.920
BT549 KIN001-244 0 2 72
BT-549 MK2206 2 72
0.001
 4711.0 4569.8 1249.6
-3.0
 1.030 1.030 1.871
BT549 MK2206 0 2 72
BT-549 MK2206 2 72
0.0032
 4598.0 4569.8 1249.6
-2.49
 1.010 1.010 1.871
BT549 MK2206 0 2 72
BT-549 MK2206 2 72
0.01
 4751.3 4569.8 1249.6
-2.0
 1.040 1.040 1.871
BT549 MK2206 0 2 72