Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-549 CAL-101 2 72
0.0032
 4767.3 4911.3 1249.6
-2.49
 0.970 0.971 1.975
BT549 CAL101 0 2 72
BT-549 CAL-101 2 72
0.01
 4791.5 4911.3 1249.6
-2.0
 0.975 0.976 1.975
BT549 CAL101 0 2 72
BT-549 CAL-101 2 72
0.032
 4864.3 4911.3 1249.6
-1.49
 0.990 0.990 1.975
BT549 CAL101 0 2 72
BT-549 CAL-101 2 72
0.1
 4768.5 4911.3 1249.6
-1.0
 0.970 0.971 1.975
BT549 CAL101 0 2 72
BT-549 CAL-101 2 72
0.32
 4658.5 4911.3 1249.6
-0.495
 0.947 0.949 1.975
BT549 CAL101 0 2 72
BT-549 CAL-101 2 72
1.0
 4324.0 4911.3 1249.6
0.0
 0.875 0.880 1.975
BT549 CAL101 0 2 72
BT-549 CAL-101 2 72
3.2
 3956.0 4911.3 1249.6
0.505
 0.792 0.805 1.975
BT549 CAL101 0 2 72
BT-549 Everolimus 2 72
0.001
 3200.5 4694.0 1249.6
-3.0
 0.637 0.682 1.909
BT549 Everolimus 0 2 72
BT-549 Everolimus 2 72
0.0032
 2956.8 4694.0 1249.6
-2.49
 0.570 0.630 1.909
BT549 Everolimus 0 2 72
BT-549 Everolimus 2 72
0.01
 3125.3 4694.0 1249.6
-2.0
 0.616 0.666 1.909
BT549 Everolimus 0 2 72
BT-549 Everolimus 2 72
0.032
 3052.5 4694.0 1249.6
-1.49
 0.596 0.650 1.909
BT549 Everolimus 0 2 72
BT-549 Everolimus 2 72
0.1
 3059.8 4694.0 1249.6
-1.0
 0.598 0.652 1.909
BT549 Everolimus 0 2 72
BT-549 Everolimus 2 72
0.32
 3022.3 4694.0 1249.6
-0.495
 0.588 0.644 1.909
BT549 Everolimus 0 2 72
BT-549 Everolimus 2 72
1.0
 2999.0 4694.0 1249.6
0.0
 0.582 0.639 1.909
BT549 Everolimus 0 2 72
BT-549 Everolimus 2 72
3.2
 2940.8 4694.0 1249.6
0.505
 0.566 0.627 1.909
BT549 Everolimus 0 2 72
BT-549 Pictilisib 2 72
0.001
 4217.3 4863.0 1249.6
-3.0
 0.860 0.867 1.960
BT549 GDC0941 0 2 72
BT-549 Pictilisib 2 72
0.0032
 4850.8 4863.0 1249.6
-2.49
 0.997 0.997 1.960
BT549 GDC0941 0 2 72
BT-549 Pictilisib 2 72
0.01
 4692.3 4863.0 1249.6
-2.0
 0.964 0.965 1.960
BT549 GDC0941 0 2 72
BT-549 Pictilisib 2 72
0.032
 4563.5 4863.0 1249.6
-1.49
 0.936 0.938 1.960
BT549 GDC0941 0 2 72
BT-549 Pictilisib 2 72
0.1
 4425.0 4863.0 1249.6
-1.0
 0.906 0.910 1.960
BT549 GDC0941 0 2 72
BT-549 Pictilisib 2 72
0.32
 3970.0 4863.0 1249.6
-0.495
 0.803 0.816 1.960
BT549 GDC0941 0 2 72
BT-549 Pictilisib 2 72
1.0
 3214.3 4863.0 1249.6
0.0
 0.619 0.661 1.960
BT549 GDC0941 0 2 72
BT-549 Pictilisib 2 72
3.2
 2299.8 4863.0 1249.6
0.505
 0.365 0.473 1.960
BT549 GDC0941 0 2 72
BT-549 GDC-0980 2 72
0.001
 4859.5 4792.0 1249.6
-3.0
 1.010 1.010 1.939
BT549 GDC0980 0 2 72
BT-549 GDC-0980 2 72
0.0032
 4745.3 4792.0 1249.6
-2.49
 0.990 0.990 1.939
BT549 GDC0980 0 2 72