Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Omipalisib | 3 | 72 | 0.032 | 723.0 | 3523.0 | 586.9 | -1.49 | 0.084 | 0.205 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.1 | 595.3 | 3523.0 | 586.9 | -1.0 | 0.005 | 0.169 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.32 | 473.0 | 3523.0 | 586.9 | -0.495 | -0.080 | 0.134 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 1.0 | 151.5 | 3523.0 | 586.9 | 0.0 | -0.408 | 0.043 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 3.2 | 59.8 | 3523.0 | 586.9 | 0.505 | -0.587 | 0.017 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 0.001 | 3545.3 | 3578.0 | 586.9 | -3.0 | 0.993 | 0.991 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 0.0032 | 3514.5 | 3578.0 | 586.9 | -2.49 | 0.986 | 0.982 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 0.01 | 3147.5 | 3578.0 | 586.9 | -2.0 | 0.904 | 0.880 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 0.032 | 3246.5 | 3578.0 | 586.9 | -1.49 | 0.927 | 0.907 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 0.1 | 3371.0 | 3578.0 | 586.9 | -1.0 | 0.955 | 0.942 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 0.32 | 3249.0 | 3578.0 | 586.9 | -0.495 | 0.927 | 0.908 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 1.0 | 3348.5 | 3578.0 | 586.9 | 0.0 | 0.950 | 0.936 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | KIN001-244 | 3 | 72 | 3.2 | 2882.0 | 3578.0 | 586.9 | 0.505 | 0.841 | 0.805 | 2.608 | BT20 KIN001-244 0 3 |
| BT-20 | MK2206 | 3 | 72 | 0.001 | 3326.5 | 3205.3 | 586.9 | -3.0 | 1.030 | 1.040 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | MK2206 | 3 | 72 | 0.0032 | 3059.8 | 3205.3 | 586.9 | -2.49 | 0.962 | 0.955 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | MK2206 | 3 | 72 | 0.01 | 3164.8 | 3205.3 | 586.9 | -2.0 | 0.990 | 0.987 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | MK2206 | 3 | 72 | 0.032 | 3388.8 | 3205.3 | 586.9 | -1.49 | 1.050 | 1.060 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | MK2206 | 3 | 72 | 0.1 | 2987.0 | 3205.3 | 586.9 | -1.0 | 0.943 | 0.932 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | MK2206 | 3 | 72 | 0.32 | 2813.8 | 3205.3 | 586.9 | -0.495 | 0.896 | 0.878 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | MK2206 | 3 | 72 | 1.0 | 2091.5 | 3205.3 | 586.9 | 0.0 | 0.680 | 0.653 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | MK2206 | 3 | 72 | 3.2 | 1018.5 | 3205.3 | 586.9 | 0.505 | 0.252 | 0.318 | 2.449 | BT20 MK2206 0 3 |
| BT-20 | PI103 | 3 | 72 | 0.001 | 3081.0 | 3311.5 | 586.9 | -3.0 | 0.943 | 0.930 | 2.496 | BT20 PI103 0 3 |
| BT-20 | PI103 | 3 | 72 | 0.0032 | 3214.5 | 3311.5 | 586.9 | -2.49 | 0.976 | 0.971 | 2.496 | BT20 PI103 0 3 |
| BT-20 | PI103 | 3 | 72 | 0.01 | 3168.3 | 3311.5 | 586.9 | -2.0 | 0.965 | 0.957 | 2.496 | BT20 PI103 0 3 |
| BT-20 | PI103 | 3 | 72 | 0.032 | 3367.3 | 3311.5 | 586.9 | -1.49 | 1.010 | 1.020 | 2.496 | BT20 PI103 0 3 |