Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-20 Buparlisib 2 72
0.0032
 2951.3 3408.8 1018.6
-2.49
 0.841 0.866 1.743
BT20 BKM120 0 2
BT-20 Buparlisib 2 72
0.01
 3295.3 3408.8 1018.6
-2.0
 0.962 0.967 1.743
BT20 BKM120 0 2
BT-20 Buparlisib 2 72
0.032
 3119.5 3408.8 1018.6
-1.49
 0.901 0.915 1.743
BT20 BKM120 0 2
BT-20 Buparlisib 2 72
0.1
 2961.3 3408.8 1018.6
-1.0
 0.845 0.869 1.743
BT20 BKM120 0 2
BT-20 Buparlisib 2 72
0.32
 2172.3 3408.8 1018.6
-0.495
 0.544 0.637 1.743
BT20 BKM120 0 2
BT-20 Buparlisib 2 72
1.0
 986.5 3408.8 1018.6
0.0
 -0.018 0.289 1.743
BT20 BKM120 0 2
BT-20 Buparlisib 2 72
3.2
 359.5 3408.8 1018.6
0.505
 -0.450 0.105 1.743
BT20 BKM120 0 2
BT-20 BX-912 2 72
0.001
 2843.0 3312.0 1018.6
-3.0
 0.828 0.858 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
0.0032
 3029.0 3312.0 1018.6
-2.49
 0.898 0.915 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
0.01
 3195.0 3312.0 1018.6
-2.0
 0.958 0.965 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
0.032
 3160.3 3312.0 1018.6
-1.49
 0.946 0.954 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
0.1
 3064.0 3312.0 1018.6
-1.0
 0.911 0.925 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
0.32
 3032.5 3312.0 1018.6
-0.495
 0.899 0.916 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
1.0
 2918.0 3312.0 1018.6
0.0
 0.857 0.881 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
3.2
 1884.8 3312.0 1018.6
0.505
 0.436 0.569 1.701
BT20 BX912 0 2
BT-20 Alpelisib 2 72
0.001
 2564.0 3290.8 1018.6
-3.0
 0.726 0.779 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.0032
 2510.5 3290.8 1018.6
-2.49
 0.704 0.763 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.01
 3212.8 3290.8 1018.6
-2.0
 0.972 0.976 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.032
 2570.0 3290.8 1018.6
-1.49
 0.728 0.781 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.1
 2742.0 3290.8 1018.6
-1.0
 0.796 0.833 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.32
 2133.8 3290.8 1018.6
-0.495
 0.548 0.648 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
1.0
 1205.3 3290.8 1018.6
0.0
 0.105 0.366 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
3.2
 853.3 3290.8 1018.6
0.505
 -0.099 0.259 1.692
BT20 BYL719 0 2
BT-20 CAL-101 2 72
0.001
 3096.0 3469.3 1018.6
-3.0
 0.875 0.892 1.768
BT20 CAL101 0 2
BT-20 CAL-101 2 72
0.0032
 3203.3 3469.3 1018.6
-2.49
 0.912 0.923 1.768
BT20 CAL101 0 2