Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
Hs 578T AS605240 2 72
0.032
 3311.5 3652.0 624.7
-1.49
 0.925 0.907 2.547
Hs578T AS605240 2
Hs 578T AS605240 2 72
0.1
 2963.3 3652.0 624.7
-1.0
 0.842 0.811 2.547
Hs578T AS605240 2
Hs 578T AS605240 2 72
0.32
 2404.3 3652.0 624.7
-0.495
 0.697 0.658 2.547
Hs578T AS605240 2
Hs 578T AS605240 2 72
1.0
 2038.8 3652.0 624.7
0.0
 0.591 0.558 2.547
Hs578T AS605240 2
Hs 578T AS605240 2 72
3.2
 1554.0 3652.0 624.7
0.505
 0.430 0.426 2.547
Hs578T AS605240 2
Hs 578T AZD-6482 2 72
0.001
 3451.8 3554.8 624.7
-3.0
 0.977 0.971 2.508
Hs578T AZD6482 2
Hs 578T AZD-6482 2 72
0.0032
 3423.3 3554.8 624.7
-2.49
 0.970 0.963 2.508
Hs578T AZD6482 2
Hs 578T AZD-6482 2 72
0.01
 3413.8 3554.8 624.7
-2.0
 0.968 0.960 2.508
Hs578T AZD6482 2
Hs 578T AZD-6482 2 72
0.032
 3279.8 3554.8 624.7
-1.49
 0.937 0.923 2.508
Hs578T AZD6482 2
Hs 578T AZD-6482 2 72
0.1
 3106.3 3554.8 624.7
-1.0
 0.895 0.874 2.508
Hs578T AZD6482 2
Hs 578T AZD-6482 2 72
0.32
 2890.3 3554.8 624.7
-0.495
 0.842 0.813 2.508
Hs578T AZD6482 2
Hs 578T AZD-6482 2 72
1.0
 2547.0 3554.8 624.7
0.0
 0.751 0.716 2.508
Hs578T AZD6482 2
Hs 578T AZD-6482 2 72
3.2
 2036.3 3554.8 624.7
0.505
 0.602 0.573 2.508
Hs578T AZD6482 2
Hs 578T AZD8055 2 72
0.001
 3406.8 3486.0 624.7
-3.0
 0.982 0.977 2.480
Hs578T AZD8055 2
Hs 578T AZD8055 2 72
0.0032
 3239.0 3486.0 624.7
-2.49
 0.942 0.929 2.480
Hs578T AZD8055 2
Hs 578T AZD8055 2 72
0.01
 2905.8 3486.0 624.7
-2.0
 0.858 0.834 2.480
Hs578T AZD8055 2
Hs 578T AZD8055 2 72
0.032
 2044.3 3486.0 624.7
-1.49
 0.613 0.586 2.480
Hs578T AZD8055 2
Hs 578T AZD8055 2 72
0.1
 1328.3 3486.0 624.7
-1.0
 0.355 0.381 2.480
Hs578T AZD8055 2
Hs 578T AZD8055 2 72
0.32
 1043.8 3486.0 624.7
-0.495
 0.230 0.299 2.480
Hs578T AZD8055 2
Hs 578T AZD8055 2 72
1.0
 890.8 3486.0 624.7
0.0
 0.154 0.256 2.480
Hs578T AZD8055 2
Hs 578T AZD8055 2 72
3.2
 881.8 3486.0 624.7
0.505
 0.149 0.253 2.480
Hs578T AZD8055 2
Hs 578T Dactolisib 2 72
0.001
 3239.3 3555.0 624.7
-3.0
 0.927 0.911 2.509
Hs578T BEZ235 2
Hs 578T Dactolisib 2 72
0.0032
 2693.5 3555.0 624.7
-2.49
 0.791 0.758 2.509
Hs578T BEZ235 2
Hs 578T Dactolisib 2 72
0.01
 1664.3 3555.0 624.7
-2.0
 0.478 0.468 2.509
Hs578T BEZ235 2
Hs 578T Dactolisib 2 72
0.032
 1207.5 3555.0 624.7
-1.49
 0.300 0.340 2.509
Hs578T BEZ235 2