Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Omipalisib | 1 | 72 | 3.2 | 169.3 | 3689.5 | 873.1 | 0.505 | -0.546 | 0.046 | 2.079 | Hs578T GSK458 1 |
| Hs 578T | KIN001-244 | 1 | 72 | 0.001 | 3543.3 | 3592.8 | 873.1 | -3.0 | 0.986 | 0.986 | 2.041 | Hs578T KIN001-244 1 |
| Hs 578T | KIN001-244 | 1 | 72 | 0.0032 | 3646.0 | 3592.8 | 873.1 | -2.49 | 1.010 | 1.010 | 2.041 | Hs578T KIN001-244 1 |
| Hs 578T | KIN001-244 | 1 | 72 | 0.01 | 3684.0 | 3592.8 | 873.1 | -2.0 | 1.020 | 1.030 | 2.041 | Hs578T KIN001-244 1 |
| Hs 578T | KIN001-244 | 1 | 72 | 0.032 | 3620.5 | 3592.8 | 873.1 | -1.49 | 1.010 | 1.010 | 2.041 | Hs578T KIN001-244 1 |
| Hs 578T | KIN001-244 | 1 | 72 | 0.1 | 3585.3 | 3592.8 | 873.1 | -1.0 | 0.998 | 0.998 | 2.041 | Hs578T KIN001-244 1 |
| Hs 578T | KIN001-244 | 1 | 72 | 0.32 | 3341.5 | 3592.8 | 873.1 | -0.495 | 0.930 | 0.930 | 2.041 | Hs578T KIN001-244 1 |
| Hs 578T | KIN001-244 | 1 | 72 | 1.0 | 3199.0 | 3592.8 | 873.1 | 0.0 | 0.889 | 0.890 | 2.041 | Hs578T KIN001-244 1 |
| Hs 578T | KIN001-244 | 1 | 72 | 3.2 | 2701.3 | 3592.8 | 873.1 | 0.505 | 0.739 | 0.752 | 2.041 | Hs578T KIN001-244 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.001 | 3510.5 | 3589.0 | 873.1 | -3.0 | 0.978 | 0.978 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.0032 | 3599.3 | 3589.0 | 873.1 | -2.49 | 1.000 | 1.000 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.01 | 3432.3 | 3589.0 | 873.1 | -2.0 | 0.957 | 0.956 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.032 | 3367.8 | 3589.0 | 873.1 | -1.49 | 0.939 | 0.938 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.1 | 3000.3 | 3589.0 | 873.1 | -1.0 | 0.832 | 0.836 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 0.32 | 2393.8 | 3589.0 | 873.1 | -0.495 | 0.640 | 0.667 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 1.0 | 2300.8 | 3589.0 | 873.1 | 0.0 | 0.608 | 0.641 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | MK2206 | 1 | 72 | 3.2 | 2752.8 | 3589.0 | 873.1 | 0.505 | 0.756 | 0.767 | 2.039 | Hs578T MK2206 1 |
| Hs 578T | PI103 | 1 | 72 | 0.001 | 3457.5 | 3645.8 | 873.1 | -3.0 | 0.949 | 0.948 | 2.062 | Hs578T PI103 1 |
| Hs 578T | PI103 | 1 | 72 | 0.0032 | 3491.0 | 3645.8 | 873.1 | -2.49 | 0.958 | 0.958 | 2.062 | Hs578T PI103 1 |
| Hs 578T | PI103 | 1 | 72 | 0.01 | 3296.8 | 3645.8 | 873.1 | -2.0 | 0.905 | 0.904 | 2.062 | Hs578T PI103 1 |
| Hs 578T | PI103 | 1 | 72 | 0.032 | 3009.5 | 3645.8 | 873.1 | -1.49 | 0.822 | 0.825 | 2.062 | Hs578T PI103 1 |
| Hs 578T | PI103 | 1 | 72 | 0.1 | 2154.8 | 3645.8 | 873.1 | -1.0 | 0.550 | 0.591 | 2.062 | Hs578T PI103 1 |
| Hs 578T | PI103 | 1 | 72 | 0.32 | 1476.3 | 3645.8 | 873.1 | -0.495 | 0.290 | 0.405 | 2.062 | Hs578T PI103 1 |
| Hs 578T | PI103 | 1 | 72 | 1.0 | 884.3 | 3645.8 | 873.1 | 0.0 | 0.006 | 0.243 | 2.062 | Hs578T PI103 1 |
| Hs 578T | PI103 | 1 | 72 | 3.2 | 744.5 | 3645.8 | 873.1 | 0.505 | -0.074 | 0.204 | 2.062 | Hs578T PI103 1 |