Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | ZSTK474 | 3 | 72 | 0.032 | 11901.8 | 11395.8 | 1273.3 | -1.49 | 1.030 | 1.040 | 3.162 | HCC1806 ZSTK474 0 3 72 |
| HCC1806 | ZSTK474 | 3 | 72 | 0.1 | 11540.8 | 11395.8 | 1273.3 | -1.0 | 1.010 | 1.010 | 3.162 | HCC1806 ZSTK474 0 3 72 |
| HCC1806 | ZSTK474 | 3 | 72 | 0.32 | 11381.0 | 11395.8 | 1273.3 | -0.495 | 0.999 | 0.999 | 3.162 | HCC1806 ZSTK474 0 3 72 |
| HCC1806 | ZSTK474 | 3 | 72 | 1.0 | 9516.5 | 11395.8 | 1273.3 | 0.0 | 0.889 | 0.835 | 3.162 | HCC1806 ZSTK474 0 3 72 |
| HCC1806 | ZSTK474 | 3 | 72 | 3.2 | 6246.0 | 11395.8 | 1273.3 | 0.505 | 0.654 | 0.548 | 3.162 | HCC1806 ZSTK474 0 3 72 |
| Hs 578T | AS605240 | 1 | 72 | 0.001 | 3614.8 | 3529.0 | 873.1 | -3.0 | 1.020 | 1.020 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 0.0032 | 3474.3 | 3529.0 | 873.1 | -2.49 | 0.985 | 0.984 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 0.01 | 3591.0 | 3529.0 | 873.1 | -2.0 | 1.020 | 1.020 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 0.032 | 3287.8 | 3529.0 | 873.1 | -1.49 | 0.931 | 0.932 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 0.1 | 2796.0 | 3529.0 | 873.1 | -1.0 | 0.782 | 0.792 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 0.32 | 2411.3 | 3529.0 | 873.1 | -0.495 | 0.656 | 0.683 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 1.0 | 1887.0 | 3529.0 | 873.1 | 0.0 | 0.466 | 0.535 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AS605240 | 1 | 72 | 3.2 | 1577.8 | 3529.0 | 873.1 | 0.505 | 0.341 | 0.447 | 2.015 | Hs578T AS605240 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 0.001 | 3637.3 | 3592.0 | 873.1 | -3.0 | 1.010 | 1.010 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 0.0032 | 3310.5 | 3592.0 | 873.1 | -2.49 | 0.922 | 0.922 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 0.01 | 3401.5 | 3592.0 | 873.1 | -2.0 | 0.947 | 0.947 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 0.032 | 3304.0 | 3592.0 | 873.1 | -1.49 | 0.920 | 0.920 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 0.1 | 3137.5 | 3592.0 | 873.1 | -1.0 | 0.872 | 0.873 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 0.32 | 2762.8 | 3592.0 | 873.1 | -0.495 | 0.759 | 0.769 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 1.0 | 2395.5 | 3592.0 | 873.1 | 0.0 | 0.640 | 0.667 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD-6482 | 1 | 72 | 3.2 | 1737.5 | 3592.0 | 873.1 | 0.505 | 0.401 | 0.484 | 2.041 | Hs578T AZD6482 1 |
| Hs 578T | AZD8055 | 1 | 72 | 0.001 | 3425.5 | 3514.5 | 873.1 | -3.0 | 0.975 | 0.975 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | AZD8055 | 1 | 72 | 0.0032 | 3097.0 | 3514.5 | 873.1 | -2.49 | 0.878 | 0.881 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | AZD8055 | 1 | 72 | 0.01 | 2770.8 | 3514.5 | 873.1 | -2.0 | 0.777 | 0.788 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | AZD8055 | 1 | 72 | 0.032 | 2220.5 | 3514.5 | 873.1 | -1.49 | 0.591 | 0.632 | 2.009 | Hs578T AZD8055 1 |