Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC1806 Sirolimus 2 72
0.0032
 9333.0 12104.5 1643.3
-2.49
 0.827 0.771 2.881
HCC1806 Rapamycin 0 2 72
HCC1806 Sirolimus 2 72
0.01
 9275.5 12104.5 1643.3
-2.0
 0.823 0.766 2.881
HCC1806 Rapamycin 0 2 72
HCC1806 Sirolimus 2 72
0.032
 9181.8 12104.5 1643.3
-1.49
 0.817 0.759 2.881
HCC1806 Rapamycin 0 2 72
HCC1806 Sirolimus 2 72
0.1
 9292.5 12104.5 1643.3
-1.0
 0.825 0.768 2.881
HCC1806 Rapamycin 0 2 72
HCC1806 Sirolimus 2 72
0.32
 8965.0 12104.5 1643.3
-0.495
 0.802 0.741 2.881
HCC1806 Rapamycin 0 2 72
HCC1806 Sirolimus 2 72
1.0
 9238.3 12104.5 1643.3
0.0
 0.821 0.763 2.881
HCC1806 Rapamycin 0 2 72
HCC1806 Sirolimus 2 72
3.2
 8674.0 12104.5 1643.3
0.505
 0.782 0.717 2.881
HCC1806 Rapamycin 0 2 72
HCC1806 TGX221 2 72
0.001
 11092.3 11158.5 1643.3
-3.0
 0.996 0.994 2.763
HCC1806 TGX221 0 2 72
HCC1806 TGX221 2 72
0.0032
 11187.8 11158.5 1643.3
-2.49
 1.000 1.000 2.763
HCC1806 TGX221 0 2 72
HCC1806 TGX221 2 72
0.01
 11230.5 11158.5 1643.3
-2.0
 1.000 1.010 2.763
HCC1806 TGX221 0 2 72
HCC1806 TGX221 2 72
0.032
 11433.8 11158.5 1643.3
-1.49
 1.020 1.020 2.763
HCC1806 TGX221 0 2 72
HCC1806 TGX221 2 72
0.1
 11446.3 11158.5 1643.3
-1.0
 1.020 1.030 2.763
HCC1806 TGX221 0 2 72
HCC1806 TGX221 2 72
0.32
 11531.3 11158.5 1643.3
-0.495
 1.020 1.030 2.763
HCC1806 TGX221 0 2 72
HCC1806 TGX221 2 72
1.0
 11205.8 11158.5 1643.3
0.0
 1.000 1.000 2.763
HCC1806 TGX221 0 2 72
HCC1806 TGX221 2 72
3.2
 11540.3 11158.5 1643.3
0.505
 1.020 1.030 2.763
HCC1806 TGX221 0 2 72
HCC1806 Torin1 2 72
0.001
 11438.8 11764.8 1643.3
-3.0
 0.980 0.972 2.840
HCC1806 Torin1 0 2 72
HCC1806 Torin1 2 72
0.0032
 11138.3 11764.8 1643.3
-2.49
 0.962 0.947 2.840
HCC1806 Torin1 0 2 72
HCC1806 Torin1 2 72
0.01
 9981.5 11764.8 1643.3
-2.0
 0.888 0.848 2.840
HCC1806 Torin1 0 2 72
HCC1806 Torin1 2 72
0.032
 8862.3 11764.8 1643.3
-1.49
 0.810 0.753 2.840
HCC1806 Torin1 0 2 72
HCC1806 Torin1 2 72
0.1
 6527.8 11764.8 1643.3
-1.0
 0.625 0.555 2.840
HCC1806 Torin1 0 2 72
HCC1806 Torin1 2 72
0.32
 5149.3 11764.8 1643.3
-0.495
 0.495 0.438 2.840
HCC1806 Torin1 0 2 72
HCC1806 Torin1 2 72
1.0
 4599.5 11764.8 1643.3
0.0
 0.437 0.391 2.840
HCC1806 Torin1 0 2 72
HCC1806 Torin1 2 72
3.2
 3197.0 11764.8 1643.3
0.505
 0.264 0.272 2.840
HCC1806 Torin1 0 2 72
HCC1806 Torin2 2 72
0.001
 11442.3 11795.0 1643.3
-3.0
 0.979 0.970 2.843
HCC1806 Torin2 0 2 72
HCC1806 Torin2 2 72
0.0032
 11163.3 11795.0 1643.3
-2.49
 0.962 0.946 2.843
HCC1806 Torin2 0 2 72