Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | Trametinib | 3 | 72 | 0.01 | 10202.5 | 11736.5 | 1273.3 | -2.0 | 0.914 | 0.869 | 3.204 | HCC1806 Trametinib 0 3 72 |
| HCC1806 | Trametinib | 3 | 72 | 0.032 | 9495.0 | 11736.5 | 1273.3 | -1.49 | 0.872 | 0.809 | 3.204 | HCC1806 Trametinib 0 3 72 |
| HCC1806 | Trametinib | 3 | 72 | 0.1 | 9344.3 | 11736.5 | 1273.3 | -1.0 | 0.863 | 0.796 | 3.204 | HCC1806 Trametinib 0 3 72 |
| HCC1806 | Trametinib | 3 | 72 | 0.32 | 8807.3 | 11736.5 | 1273.3 | -0.495 | 0.829 | 0.750 | 3.204 | HCC1806 Trametinib 0 3 72 |
| HCC1806 | Trametinib | 3 | 72 | 1.0 | 8710.3 | 11736.5 | 1273.3 | 0.0 | 0.822 | 0.742 | 3.204 | HCC1806 Trametinib 0 3 72 |
| HCC1806 | Trametinib | 3 | 72 | 3.2 | 8956.8 | 11736.5 | 1273.3 | 0.505 | 0.838 | 0.763 | 3.204 | HCC1806 Trametinib 0 3 72 |
| HCC1806 | WYE-125132 | 3 | 72 | 0.001 | 11365.0 | 12050.8 | 1273.3 | -3.0 | 0.964 | 0.943 | 3.242 | HCC1806 WYE125132 0 3 72 |
| HCC1806 | WYE-125132 | 3 | 72 | 0.0032 | 11072.0 | 12050.8 | 1273.3 | -2.49 | 0.948 | 0.919 | 3.242 | HCC1806 WYE125132 0 3 72 |
| HCC1806 | WYE-125132 | 3 | 72 | 0.01 | 10352.8 | 12050.8 | 1273.3 | -2.0 | 0.908 | 0.859 | 3.242 | HCC1806 WYE125132 0 3 72 |
| HCC1806 | WYE-125132 | 3 | 72 | 0.032 | 8601.3 | 12050.8 | 1273.3 | -1.49 | 0.802 | 0.714 | 3.242 | HCC1806 WYE125132 0 3 72 |
| HCC1806 | WYE-125132 | 3 | 72 | 0.1 | 6801.8 | 12050.8 | 1273.3 | -1.0 | 0.677 | 0.564 | 3.242 | HCC1806 WYE125132 0 3 72 |
| HCC1806 | WYE-125132 | 3 | 72 | 0.32 | 5594.8 | 12050.8 | 1273.3 | -0.495 | 0.579 | 0.464 | 3.242 | HCC1806 WYE125132 0 3 72 |
| HCC1806 | WYE-125132 | 3 | 72 | 1.0 | 5290.0 | 12050.8 | 1273.3 | 0.0 | 0.552 | 0.439 | 3.242 | HCC1806 WYE125132 0 3 72 |
| HCC1806 | WYE-125132 | 3 | 72 | 3.2 | 5062.8 | 12050.8 | 1273.3 | 0.505 | 0.531 | 0.420 | 3.242 | HCC1806 WYE125132 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.001 | 11248.3 | 11581.0 | 1273.3 | -3.0 | 0.982 | 0.971 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.0032 | 11345.3 | 11581.0 | 1273.3 | -2.49 | 0.987 | 0.980 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.01 | 11593.8 | 11581.0 | 1273.3 | -2.0 | 1.000 | 1.000 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.032 | 11500.3 | 11581.0 | 1273.3 | -1.49 | 0.996 | 0.993 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.1 | 11258.8 | 11581.0 | 1273.3 | -1.0 | 0.982 | 0.972 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.32 | 11645.5 | 11581.0 | 1273.3 | -0.495 | 1.000 | 1.010 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 1.0 | 11919.8 | 11581.0 | 1273.3 | 0.0 | 1.020 | 1.030 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 3.2 | 12161.5 | 11581.0 | 1273.3 | 0.505 | 1.030 | 1.050 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | ZSTK474 | 3 | 72 | 0.001 | 11415.3 | 11395.8 | 1273.3 | -3.0 | 1.000 | 1.000 | 3.162 | HCC1806 ZSTK474 0 3 72 |
| HCC1806 | ZSTK474 | 3 | 72 | 0.0032 | 11595.8 | 11395.8 | 1273.3 | -2.49 | 1.010 | 1.020 | 3.162 | HCC1806 ZSTK474 0 3 72 |
| HCC1806 | ZSTK474 | 3 | 72 | 0.01 | 11648.8 | 11395.8 | 1273.3 | -2.0 | 1.010 | 1.020 | 3.162 | HCC1806 ZSTK474 0 3 72 |