Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
Hs 578T KIN001-244 2 72
3.2
 2795.8 3546.3 624.7
0.505
 0.819 0.788 2.505
Hs578T KIN001-244 2
Hs 578T MK2206 2 72
0.001
 3466.3 3607.8 624.7
-3.0
 0.969 0.961 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
0.0032
 3583.0 3607.8 624.7
-2.49
 0.995 0.993 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
0.01
 3314.8 3607.8 624.7
-2.0
 0.934 0.919 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
0.032
 3360.8 3607.8 624.7
-1.49
 0.945 0.932 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
0.1
 3038.5 3607.8 624.7
-1.0
 0.869 0.842 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
0.32
 2629.8 3607.8 624.7
-0.495
 0.765 0.729 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
1.0
 2266.0 3607.8 624.7
0.0
 0.664 0.628 2.530
Hs578T MK2206 2
Hs 578T MK2206 2 72
3.2
 2956.8 3607.8 624.7
0.505
 0.849 0.820 2.530
Hs578T MK2206 2
Hs 578T PI103 2 72
0.001
 3443.8 3540.3 624.7
-3.0
 0.978 0.973 2.503
Hs578T PI103 2
Hs 578T PI103 2 72
0.0032
 3439.5 3540.3 624.7
-2.49
 0.977 0.972 2.503
Hs578T PI103 2
Hs 578T PI103 2 72
0.01
 3281.0 3540.3 624.7
-2.0
 0.940 0.927 2.503
Hs578T PI103 2
Hs 578T PI103 2 72
0.032
 3009.3 3540.3 624.7
-1.49
 0.874 0.850 2.503
Hs578T PI103 2
Hs 578T PI103 2 72
0.1
 2244.5 3540.3 624.7
-1.0
 0.667 0.634 2.503
Hs578T PI103 2
Hs 578T PI103 2 72
0.32
 1466.8 3540.3 624.7
-0.495
 0.406 0.414 2.503
Hs578T PI103 2
Hs 578T PI103 2 72
1.0
 919.5 3540.3 624.7
0.0
 0.167 0.260 2.503
Hs578T PI103 2
Hs 578T PI103 2 72
3.2
 592.0 3540.3 624.7
0.505
 -0.021 0.167 2.503
Hs578T PI103 2
Hs 578T PIK-93 2 72
0.001
 3518.8 3455.0 624.7
-3.0
 1.010 1.020 2.467
Hs578T PIK93 2
Hs 578T PIK-93 2 72
0.0032
 3485.0 3455.0 624.7
-2.49
 1.010 1.010 2.467
Hs578T PIK93 2
Hs 578T PIK-93 2 72
0.01
 3583.5 3455.0 624.7
-2.0
 1.030 1.040 2.467
Hs578T PIK93 2
Hs 578T PIK-93 2 72
0.032
 3509.5 3455.0 624.7
-1.49
 1.010 1.020 2.467
Hs578T PIK93 2
Hs 578T PIK-93 2 72
0.1
 3353.0 3455.0 624.7
-1.0
 0.976 0.970 2.467
Hs578T PIK93 2
Hs 578T PIK-93 2 72
0.32
 2926.3 3455.0 624.7
-0.495
 0.870 0.847 2.467
Hs578T PIK93 2
Hs 578T PIK-93 2 72
1.0
 2449.0 3455.0 624.7
0.0
 0.740 0.709 2.467
Hs578T PIK93 2
Hs 578T PIK-93 2 72
3.2
 1472.3 3455.0 624.7
0.505
 0.415 0.426 2.467
Hs578T PIK93 2