Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
Hs 578T Sirolimus 2 72
0.001
 2357.5 3624.0 624.7
-3.0
 0.688 0.651 2.536
Hs578T Rapamycin 2
Hs 578T Sirolimus 2 72
0.0032
 2359.5 3624.0 624.7
-2.49
 0.689 0.651 2.536
Hs578T Rapamycin 2
Hs 578T Sirolimus 2 72
0.01
 2232.5 3624.0 624.7
-2.0
 0.652 0.616 2.536
Hs578T Rapamycin 2
Hs 578T Sirolimus 2 72
0.032
 2298.8 3624.0 624.7
-1.49
 0.671 0.634 2.536
Hs578T Rapamycin 2
Hs 578T Sirolimus 2 72
0.1
 2243.0 3624.0 624.7
-1.0
 0.655 0.619 2.536
Hs578T Rapamycin 2
Hs 578T Sirolimus 2 72
0.32
 2240.8 3624.0 624.7
-0.495
 0.655 0.618 2.536
Hs578T Rapamycin 2
Hs 578T Sirolimus 2 72
1.0
 2134.8 3624.0 624.7
0.0
 0.623 0.589 2.536
Hs578T Rapamycin 2
Hs 578T Sirolimus 2 72
3.2
 2223.3 3624.0 624.7
0.505
 0.650 0.613 2.536
Hs578T Rapamycin 2
Hs 578T TGX221 2 72
0.001
 3441.5 3441.3 624.7
-3.0
 1.000 1.000 2.462
Hs578T TGX221 2
Hs 578T TGX221 2 72
0.0032
 3568.3 3441.3 624.7
-2.49
 1.030 1.040 2.462
Hs578T TGX221 2
Hs 578T TGX221 2 72
0.01
 3496.5 3441.3 624.7
-2.0
 1.010 1.020 2.462
Hs578T TGX221 2
Hs 578T TGX221 2 72
0.032
 3499.3 3441.3 624.7
-1.49
 1.010 1.020 2.462
Hs578T TGX221 2
Hs 578T TGX221 2 72
0.1
 3375.5 3441.3 624.7
-1.0
 0.984 0.981 2.462
Hs578T TGX221 2
Hs 578T TGX221 2 72
0.32
 3235.0 3441.3 624.7
-0.495
 0.950 0.940 2.462
Hs578T TGX221 2
Hs 578T TGX221 2 72
1.0
 2980.3 3441.3 624.7
0.0
 0.886 0.866 2.462
Hs578T TGX221 2
Hs 578T TGX221 2 72
3.2
 2715.3 3441.3 624.7
0.505
 0.816 0.789 2.462
Hs578T TGX221 2
Hs 578T Torin1 2 72
0.001
 3381.5 3653.5 624.7
-3.0
 0.940 0.926 2.548
Hs578T Torin1 2
Hs 578T Torin1 2 72
0.0032
 3042.0 3653.5 624.7
-2.49
 0.861 0.833 2.548
Hs578T Torin1 2
Hs 578T Torin1 2 72
0.01
 2208.3 3653.5 624.7
-2.0
 0.641 0.604 2.548
Hs578T Torin1 2
Hs 578T Torin1 2 72
0.032
 1511.3 3653.5 624.7
-1.49
 0.414 0.414 2.548
Hs578T Torin1 2
Hs 578T Torin1 2 72
0.1
 1119.5 3653.5 624.7
-1.0
 0.257 0.306 2.548
Hs578T Torin1 2
Hs 578T Torin1 2 72
0.32
 929.3 3653.5 624.7
-0.495
 0.169 0.254 2.548
Hs578T Torin1 2
Hs 578T Torin1 2 72
1.0
 901.0 3653.5 624.7
0.0
 0.155 0.247 2.548
Hs578T Torin1 2
Hs 578T Torin1 2 72
3.2
 879.8 3653.5 624.7
0.505
 0.144 0.241 2.548
Hs578T Torin1 2
Hs 578T Torin2 2 72
0.001
 3230.5 3604.3 624.7
-3.0
 0.915 0.896 2.528
Hs578T Torin2 2