Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Trametinib | 3 | 72 | 0.0032 | 2571.8 | 4062.0 | 571.3 | -2.49 | 0.702 | 0.633 | 2.830 | Hs578T Trametinib 3 |
| Hs 578T | Trametinib | 3 | 72 | 0.01 | 2013.8 | 4062.0 | 571.3 | -2.0 | 0.561 | 0.496 | 2.830 | Hs578T Trametinib 3 |
| Hs 578T | Trametinib | 3 | 72 | 0.032 | 1351.8 | 4062.0 | 571.3 | -1.49 | 0.356 | 0.333 | 2.830 | Hs578T Trametinib 3 |
| Hs 578T | Trametinib | 3 | 72 | 0.1 | 969.5 | 4062.0 | 571.3 | -1.0 | 0.205 | 0.239 | 2.830 | Hs578T Trametinib 3 |
| Hs 578T | Trametinib | 3 | 72 | 0.32 | 779.3 | 4062.0 | 571.3 | -0.495 | 0.116 | 0.192 | 2.830 | Hs578T Trametinib 3 |
| Hs 578T | Trametinib | 3 | 72 | 1.0 | 735.3 | 4062.0 | 571.3 | 0.0 | 0.093 | 0.181 | 2.830 | Hs578T Trametinib 3 |
| Hs 578T | Trametinib | 3 | 72 | 3.2 | 684.0 | 4062.0 | 571.3 | 0.505 | 0.066 | 0.168 | 2.830 | Hs578T Trametinib 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.001 | 3852.0 | 4195.3 | 571.3 | -3.0 | 0.942 | 0.918 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.0032 | 3689.8 | 4195.3 | 571.3 | -2.49 | 0.913 | 0.880 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.01 | 3335.5 | 4195.3 | 571.3 | -2.0 | 0.847 | 0.795 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.032 | 2208.3 | 4195.3 | 571.3 | -1.49 | 0.600 | 0.526 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.1 | 1489.8 | 4195.3 | 571.3 | -1.0 | 0.395 | 0.355 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.32 | 1162.5 | 4195.3 | 571.3 | -0.495 | 0.280 | 0.277 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 1.0 | 1048.5 | 4195.3 | 571.3 | 0.0 | 0.235 | 0.250 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 3.2 | 940.0 | 4195.3 | 571.3 | 0.505 | 0.189 | 0.224 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | XL147 | 3 | 72 | 0.001 | 4128.5 | 4203.0 | 571.3 | -3.0 | 0.988 | 0.982 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.0032 | 4271.5 | 4203.0 | 571.3 | -2.49 | 1.010 | 1.020 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.01 | 4398.8 | 4203.0 | 571.3 | -2.0 | 1.030 | 1.050 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.032 | 4383.0 | 4203.0 | 571.3 | -1.49 | 1.030 | 1.040 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.1 | 4330.0 | 4203.0 | 571.3 | -1.0 | 1.020 | 1.030 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.32 | 4162.5 | 4203.0 | 571.3 | -0.495 | 0.993 | 0.990 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 1.0 | 4068.5 | 4203.0 | 571.3 | 0.0 | 0.978 | 0.968 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 3.2 | 4031.5 | 4203.0 | 571.3 | 0.505 | 0.971 | 0.959 | 2.879 | Hs578T XL147 3 |
| Hs 578T | ZSTK474 | 3 | 72 | 0.001 | 4138.3 | 4157.8 | 571.3 | -3.0 | 0.997 | 0.995 | 2.863 | Hs578T ZSTK474 3 |
| Hs 578T | ZSTK474 | 3 | 72 | 0.0032 | 4190.3 | 4157.8 | 571.3 | -2.49 | 1.010 | 1.010 | 2.863 | Hs578T ZSTK474 3 |