Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Everolimus | 1 | 72 | 1.0 | 2363.3 | 3566.8 | 873.1 | 0.0 | 0.633 | 0.663 | 2.030 | Hs578T Everolimus 1 |
| Hs 578T | Everolimus | 1 | 72 | 3.2 | 2344.0 | 3566.8 | 873.1 | 0.505 | 0.626 | 0.657 | 2.030 | Hs578T Everolimus 1 |
| Hs 578T | Pictilisib | 1 | 72 | 0.001 | 3572.8 | 3610.0 | 873.1 | -3.0 | 0.990 | 0.990 | 2.048 | Hs578T GDC0941 1 |
| Hs 578T | Pictilisib | 1 | 72 | 0.0032 | 3486.5 | 3610.0 | 873.1 | -2.49 | 0.966 | 0.966 | 2.048 | Hs578T GDC0941 1 |
| Hs 578T | Pictilisib | 1 | 72 | 0.01 | 3409.5 | 3610.0 | 873.1 | -2.0 | 0.945 | 0.944 | 2.048 | Hs578T GDC0941 1 |
| Hs 578T | Pictilisib | 1 | 72 | 0.032 | 3119.8 | 3610.0 | 873.1 | -1.49 | 0.862 | 0.864 | 2.048 | Hs578T GDC0941 1 |
| Hs 578T | Pictilisib | 1 | 72 | 0.1 | 2586.5 | 3610.0 | 873.1 | -1.0 | 0.700 | 0.716 | 2.048 | Hs578T GDC0941 1 |
| Hs 578T | Pictilisib | 1 | 72 | 0.32 | 2146.5 | 3610.0 | 873.1 | -0.495 | 0.552 | 0.595 | 2.048 | Hs578T GDC0941 1 |
| Hs 578T | Pictilisib | 1 | 72 | 1.0 | 1847.3 | 3610.0 | 873.1 | 0.0 | 0.442 | 0.512 | 2.048 | Hs578T GDC0941 1 |
| Hs 578T | Pictilisib | 1 | 72 | 3.2 | 1591.5 | 3610.0 | 873.1 | 0.505 | 0.341 | 0.441 | 2.048 | Hs578T GDC0941 1 |
| Hs 578T | GDC-0980 | 1 | 72 | 0.001 | 3536.3 | 3454.8 | 873.1 | -3.0 | 1.020 | 1.020 | 1.984 | Hs578T GDC0980 1 |
| Hs 578T | GDC-0980 | 1 | 72 | 0.0032 | 3434.0 | 3454.8 | 873.1 | -2.49 | 0.994 | 0.994 | 1.984 | Hs578T GDC0980 1 |
| Hs 578T | GDC-0980 | 1 | 72 | 0.01 | 3206.0 | 3454.8 | 873.1 | -2.0 | 0.926 | 0.928 | 1.984 | Hs578T GDC0980 1 |
| Hs 578T | GDC-0980 | 1 | 72 | 0.032 | 2799.0 | 3454.8 | 873.1 | -1.49 | 0.799 | 0.810 | 1.984 | Hs578T GDC0980 1 |
| Hs 578T | GDC-0980 | 1 | 72 | 0.1 | 1992.0 | 3454.8 | 873.1 | -1.0 | 0.515 | 0.577 | 1.984 | Hs578T GDC0980 1 |
| Hs 578T | GDC-0980 | 1 | 72 | 0.32 | 1383.5 | 3454.8 | 873.1 | -0.495 | 0.261 | 0.400 | 1.984 | Hs578T GDC0980 1 |
| Hs 578T | GDC-0980 | 1 | 72 | 1.0 | 1032.0 | 3454.8 | 873.1 | 0.0 | 0.088 | 0.299 | 1.984 | Hs578T GDC0980 1 |
| Hs 578T | GDC-0980 | 1 | 72 | 3.2 | 774.3 | 3454.8 | 873.1 | 0.505 | -0.059 | 0.224 | 1.984 | Hs578T GDC0980 1 |
| Hs 578T | Omipalisib | 1 | 72 | 0.001 | 2420.5 | 3689.5 | 873.1 | -3.0 | 0.633 | 0.656 | 2.079 | Hs578T GSK458 1 |
| Hs 578T | Omipalisib | 1 | 72 | 0.0032 | 2199.5 | 3689.5 | 873.1 | -2.49 | 0.560 | 0.596 | 2.079 | Hs578T GSK458 1 |
| Hs 578T | Omipalisib | 1 | 72 | 0.01 | 1736.3 | 3689.5 | 873.1 | -2.0 | 0.392 | 0.471 | 2.079 | Hs578T GSK458 1 |
| Hs 578T | Omipalisib | 1 | 72 | 0.032 | 1407.8 | 3689.5 | 873.1 | -1.49 | 0.258 | 0.382 | 2.079 | Hs578T GSK458 1 |
| Hs 578T | Omipalisib | 1 | 72 | 0.1 | 1147.3 | 3689.5 | 873.1 | -1.0 | 0.140 | 0.311 | 2.079 | Hs578T GSK458 1 |
| Hs 578T | Omipalisib | 1 | 72 | 0.32 | 823.3 | 3689.5 | 873.1 | -0.495 | -0.028 | 0.223 | 2.079 | Hs578T GSK458 1 |
| Hs 578T | Omipalisib | 1 | 72 | 1.0 | 465.3 | 3689.5 | 873.1 | 0.0 | -0.261 | 0.126 | 2.079 | Hs578T GSK458 1 |