Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | AZD-6482 | 3 | 72 | 0.1 | 12053.8 | 11709.8 | 1273.3 | -1.0 | 1.020 | 1.030 | 3.201 | HCC1806 AZD6482 0 3 72 |
| HCC1806 | AZD-6482 | 3 | 72 | 0.32 | 11558.3 | 11709.8 | 1273.3 | -0.495 | 0.992 | 0.987 | 3.201 | HCC1806 AZD6482 0 3 72 |
| HCC1806 | AZD-6482 | 3 | 72 | 1.0 | 11781.3 | 11709.8 | 1273.3 | 0.0 | 1.000 | 1.010 | 3.201 | HCC1806 AZD6482 0 3 72 |
| HCC1806 | AZD-6482 | 3 | 72 | 3.2 | 11967.3 | 11709.8 | 1273.3 | 0.505 | 1.010 | 1.020 | 3.201 | HCC1806 AZD6482 0 3 72 |
| HCC1806 | AZD8055 | 3 | 72 | 0.001 | 11605.5 | 11579.3 | 1273.3 | -3.0 | 1.000 | 1.000 | 3.185 | HCC1806 AZD8055 0 3 72 |
| HCC1806 | AZD8055 | 3 | 72 | 0.0032 | 11161.5 | 11579.3 | 1273.3 | -2.49 | 0.977 | 0.964 | 3.185 | HCC1806 AZD8055 0 3 72 |
| HCC1806 | AZD8055 | 3 | 72 | 0.01 | 10460.5 | 11579.3 | 1273.3 | -2.0 | 0.937 | 0.903 | 3.185 | HCC1806 AZD8055 0 3 72 |
| HCC1806 | AZD8055 | 3 | 72 | 0.032 | 9150.5 | 11579.3 | 1273.3 | -1.49 | 0.858 | 0.790 | 3.185 | HCC1806 AZD8055 0 3 72 |
| HCC1806 | AZD8055 | 3 | 72 | 0.1 | 7212.5 | 11579.3 | 1273.3 | -1.0 | 0.724 | 0.623 | 3.185 | HCC1806 AZD8055 0 3 72 |
| HCC1806 | AZD8055 | 3 | 72 | 0.32 | 5696.0 | 11579.3 | 1273.3 | -0.495 | 0.601 | 0.492 | 3.185 | HCC1806 AZD8055 0 3 72 |
| HCC1806 | AZD8055 | 3 | 72 | 1.0 | 5727.5 | 11579.3 | 1273.3 | 0.0 | 0.603 | 0.495 | 3.185 | HCC1806 AZD8055 0 3 72 |
| HCC1806 | AZD8055 | 3 | 72 | 3.2 | 5607.0 | 11579.3 | 1273.3 | 0.505 | 0.593 | 0.484 | 3.185 | HCC1806 AZD8055 0 3 72 |
| HCC1806 | Dactolisib | 3 | 72 | 0.001 | 11630.8 | 11670.0 | 1273.3 | -3.0 | 0.998 | 0.997 | 3.196 | HCC1806 BEZ235 0 3 72 |
| HCC1806 | Dactolisib | 3 | 72 | 0.0032 | 10570.3 | 11670.0 | 1273.3 | -2.49 | 0.939 | 0.906 | 3.196 | HCC1806 BEZ235 0 3 72 |
| HCC1806 | Dactolisib | 3 | 72 | 0.01 | 9243.3 | 11670.0 | 1273.3 | -2.0 | 0.859 | 0.792 | 3.196 | HCC1806 BEZ235 0 3 72 |
| HCC1806 | Dactolisib | 3 | 72 | 0.032 | 7096.0 | 11670.0 | 1273.3 | -1.49 | 0.712 | 0.608 | 3.196 | HCC1806 BEZ235 0 3 72 |
| HCC1806 | Dactolisib | 3 | 72 | 0.1 | 6060.8 | 11670.0 | 1273.3 | -1.0 | 0.629 | 0.519 | 3.196 | HCC1806 BEZ235 0 3 72 |
| HCC1806 | Dactolisib | 3 | 72 | 0.32 | 4335.3 | 11670.0 | 1273.3 | -0.495 | 0.467 | 0.371 | 3.196 | HCC1806 BEZ235 0 3 72 |
| HCC1806 | Dactolisib | 3 | 72 | 1.0 | 1879.0 | 11670.0 | 1273.3 | 0.0 | 0.129 | 0.161 | 3.196 | HCC1806 BEZ235 0 3 72 |
| HCC1806 | Dactolisib | 3 | 72 | 3.2 | 1409.8 | 11670.0 | 1273.3 | 0.505 | 0.032 | 0.121 | 3.196 | HCC1806 BEZ235 0 3 72 |
| HCC1806 | Buparlisib | 3 | 72 | 0.001 | 11516.0 | 11660.8 | 1273.3 | -3.0 | 0.992 | 0.988 | 3.195 | HCC1806 BKM120 0 3 72 |
| HCC1806 | Buparlisib | 3 | 72 | 0.0032 | 11494.8 | 11660.8 | 1273.3 | -2.49 | 0.991 | 0.986 | 3.195 | HCC1806 BKM120 0 3 72 |
| HCC1806 | Buparlisib | 3 | 72 | 0.01 | 11603.0 | 11660.8 | 1273.3 | -2.0 | 0.997 | 0.995 | 3.195 | HCC1806 BKM120 0 3 72 |
| HCC1806 | Buparlisib | 3 | 72 | 0.032 | 11523.5 | 11660.8 | 1273.3 | -1.49 | 0.993 | 0.988 | 3.195 | HCC1806 BKM120 0 3 72 |
| HCC1806 | Buparlisib | 3 | 72 | 0.1 | 11343.3 | 11660.8 | 1273.3 | -1.0 | 0.983 | 0.973 | 3.195 | HCC1806 BKM120 0 3 72 |