LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20362)

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Cell Small Molecule Timepoint GR50 GRmax GR_AOC GEC50 GRinf h_GR r2_GR pval_GR
MCF10A-GM_7
 Palbociclib 72
1.4192
 0.1315 0.1975 0.46657 0.3096 0.8680 0.8643
1.44168010863e-11
MCF10A-GM_5
 Palbociclib 72
1.3443
 0.1381 0.2526 0.87951 0.1153 0.6180 0.9252
8.43769498715e-15
MCF10A-GM_9
 Palbociclib 72
1.9908
 0.2644 0.1774 0.63833 0.3431 1.0190 0.9267
6.43929354283e-15
MCF10A-GM_8
 Palbociclib 72
2.0079
 0.2005 0.1953 0.67438 0.2875 0.7841 0.9289
4.4408920985e-15
MCF10A-GM_4
 Palbociclib 72
1.2786
 0.1204 0.2510 1.13395 0.0360 0.6224 0.9308
3.10862446895e-15
MCF10A-GM_6
 Palbociclib 72
1.6855
 0.1558 0.2242 1.17921 0.1046 0.6573 0.9371
9.99200722163e-16
MCF10A-GM_2
 Palbociclib 72
0.6209
 0.1517 0.3099 0.48785 0.0759 0.6830 0.9438
2.22044604925e-16
MCF10A-GM_8
 Neratinib 72
0.6706
 0.1160 0.1824 0.54699 0.1232 1.3890 0.9508
4.10782519111e-15
MCF10A-GM_8
 Alpelisib 72
17.8393
 0.5275 0.0998 138.06189 -1.0000 0.5369 0.9510
3.88578058619e-15
MCF10A-GM_9
 Alpelisib 72
40.5553
 0.6142 0.0999 7.33308 0.3417 0.6724 0.9520
1.43218770177e-14
MCF10A-GM_7
 Neratinib 72
0.7004
 0.1524 0.1795 0.49822 0.2115 1.6140 0.9562
1.11022302463e-15
MCF10A-GM_4
 Neratinib 72
0.3213
 0.0948 0.2421 0.25816 0.1783 2.0143 0.9600
4.4408920985e-16
MCF10A-GM_4
 Alpelisib 72
14.7321
 0.5350 0.1188 119.95795 -1.0000 0.5239 0.9638
1.11022302463e-16
MCF10A-GM_9
 Neratinib 72
0.7213
 0.1590 0.1769 0.54736 0.1720 1.5274 0.9640
1.11022302463e-16
MCF10A-GM_3
 Palbociclib 72
0.8312
 0.1260 0.2902 0.65210 0.0722 0.6423 0.9643
1.11022302463e-16
MCF10A-GM_1
 Palbociclib 72
0.5322
 0.1211 0.3355 0.54895 -0.0094 0.5976 0.9648
1.11022302463e-16
MCF10A-GM_7
 Alpelisib 72
inf
 0.5800 0.1011 1.84960 0.5587 0.9359 0.9686
1.11022302463e-16
MCF10A-GM_5
 Neratinib 72
0.3964
 0.1078 0.2346 0.32649 0.1311 1.5671 0.9720
1.11022302463e-16
MCF10A-GM_6
 Neratinib 72
0.3761
 0.1070 0.2321 0.31111 0.1441 1.7915 0.9747
1.11022302463e-16
MCF10A-GM_2
 Alpelisib 72
14.1515
 0.5378 0.1207 7.55411 0.1758 0.6903 0.9747
1.11022302463e-16
MCF10A-GM_5
 Trametinib 72
0.0055
 0.1290 0.5670 0.00383 0.1779 1.2083 0.9766
1.11022302463e-16
MCF10A-GM_6
 Alpelisib 72
13.6674
 0.5343 0.1095 92.70681 -1.0000 0.5739 0.9770
1.11022302463e-16
MCF10A-GM_7
 Vorinostat 72
2.2366
 0.0823 0.2018 2.22508 0.0042 1.6213 0.9772
3.23052695705e-12
MCF10A-GM_2
 Dasatinib 72
0.5372
 -0.0593 0.3896 1.05022 -0.2667 0.6377 0.9780
1.11022302463e-16
MCF10A-GM_9
 Dasatinib 72
0.8384
 -0.0654 0.3421 1.94935 -0.3664 0.6515 0.9807
1.11022302463e-16
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