LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20362)

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Cell Small Molecule Timepoint GR50 GRmax GR_AOC GEC50 GRinf h_GR r2_GR pval_GR
MCF10A-GM_8
 Alpelisib 72
17.8393
 0.5275 0.0998 138.06189 -1.0000 0.5369 0.9510
3.88578058619e-15
MCF10A-GM_9
 Alpelisib 72
40.5553
 0.6142 0.0999 7.33308 0.3417 0.6724 0.9520
1.43218770177e-14
MCF10A-GM_7
 Alpelisib 72
inf
 0.5800 0.1011 1.84960 0.5587 0.9359 0.9686
1.11022302463e-16
MCF10A-GM_6
 Alpelisib 72
13.6674
 0.5343 0.1095 92.70681 -1.0000 0.5739 0.9770
1.11022302463e-16
MCF10A-GM_5
 Alpelisib 72
12.6322
 0.5207 0.1108 81.30890 -1.0000 0.5900 0.9846
1.11022302463e-16
MCF10A-GM_3
 Alpelisib 72
12.9167
 0.5328 0.1116 73.65654 -0.8864 0.5858 0.9876
1.11022302463e-16
MCF10A-GM_1
 Alpelisib 72
16.8047
 0.5253 0.1124 16.38007 0.0074 0.5799 0.9822
1.11022302463e-16
MCF10A-GM_4
 Alpelisib 72
14.7321
 0.5350 0.1188 119.95795 -1.0000 0.5239 0.9638
1.11022302463e-16
MCF10A-GM_2
 Alpelisib 72
14.1515
 0.5378 0.1207 7.55411 0.1758 0.6903 0.9747
1.11022302463e-16
MCF10A-GM_9
 Neratinib 72
0.7213
 0.1590 0.1769 0.54736 0.1720 1.5274 0.9640
1.11022302463e-16
MCF10A-GM_9
 Palbociclib 72
1.9908
 0.2644 0.1774 0.63833 0.3431 1.0190 0.9267
6.43929354283e-15
MCF10A-GM_7
 Neratinib 72
0.7004
 0.1524 0.1795 0.49822 0.2115 1.6140 0.9562
1.11022302463e-15
MCF10A-GM_8
 Neratinib 72
0.6706
 0.1160 0.1824 0.54699 0.1232 1.3890 0.9508
4.10782519111e-15
MCF10A-GM_9
 Vorinostat 72
2.5965
 0.1036 0.1840 2.74842 -0.0412 1.3907 0.9875
4.86277684786e-14
MCF10A-GM_8
 Palbociclib 72
2.0079
 0.2005 0.1953 0.67438 0.2875 0.7841 0.9289
4.4408920985e-15
MCF10A-GM_7
 Palbociclib 72
1.4192
 0.1315 0.1975 0.46657 0.3096 0.8680 0.8643
1.44168010863e-11
MCF10A-GM_8
 Vorinostat 72
2.2688
 0.0809 0.2004 2.38912 -0.0375 1.3994 0.9846
2.06834549488e-13
MCF10A-GM_7
 Vorinostat 72
2.2366
 0.0823 0.2018 2.22508 0.0042 1.6213 0.9772
3.23052695705e-12
MCF10A-GM_5
 Vorinostat 72
2.0845
 0.0606 0.2051 2.11031 -0.0098 1.5706 0.9910
4.77395900589e-15
MCF10A-GM_6
 Vorinostat 72
2.02
 0.0947 0.2066 1.88917 0.0560 1.7751 0.9873
5.38458166943e-14
MCF10A-GM_4
 Vorinostat 72
1.8157
 0.0972 0.2199 1.71251 0.0463 1.6610 0.9854
1.44551037806e-13
MCF10A-GM_6
 Palbociclib 72
1.6855
 0.1558 0.2242 1.17921 0.1046 0.6573 0.9371
9.99200722163e-16
MCF10A-GM_1
 Vorinostat 72
1.6326
 0.0800 0.2269 1.55546 0.0392 1.6875 0.9975
1.11022302463e-16
MCF10A-GM_6
 Neratinib 72
0.3761
 0.1070 0.2321 0.31111 0.1441 1.7915 0.9747
1.11022302463e-16
MCF10A-GM_5
 Neratinib 72
0.3964
 0.1078 0.2346 0.32649 0.1311 1.5671 0.9720
1.11022302463e-16
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