LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20362)

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Cell Small Molecule Timepoint GR50 GRmax GR_AOC GEC50 GRinf h_GR r2_GR pval_GR
MCF10A-GM_1
 Alpelisib 72
16.8047
 0.5253 0.1124 16.38007 0.0074 0.5799 0.9822
1.11022302463e-16
MCF10A-GM_1
 Dasatinib 72
0.4799
 -0.0596 0.4113 0.84280 -0.2282 0.6676 0.9832
1.11022302463e-16
MCF10A-GM_1
 Etoposide 72
0.2477
 0.0271 0.4660 0.24946 -0.0050 1.4185 0.9937
1.11022302463e-16
MCF10A-GM_1
 Neratinib 72
0.1689
 0.0559 0.3305 0.14681 0.0997 1.5846 0.9862
1.11022302463e-16
MCF10A-GM_1
 Taxol 72
0.0031
 -0.1839 0.7432 0.00360 -0.1412 1.8163 0.9877
1.11022302463e-16
MCF10A-GM_1
 Palbociclib 72
0.5322
 0.1211 0.3355 0.54895 -0.0094 0.5976 0.9648
1.11022302463e-16
MCF10A-GM_1
 Trametinib 72
0.0036
 0.1788 0.6024 0.00255 0.1811 1.2634 0.9812
1.11022302463e-16
MCF10A-GM_1
 Vorinostat 72
1.6326
 0.0800 0.2269 1.55546 0.0392 1.6875 0.9975
1.11022302463e-16
MCF10A-GM_2
 Alpelisib 72
14.1515
 0.5378 0.1207 7.55411 0.1758 0.6903 0.9747
1.11022302463e-16
MCF10A-GM_2
 Dasatinib 72
0.5372
 -0.0593 0.3896 1.05022 -0.2667 0.6377 0.9780
1.11022302463e-16
MCF10A-GM_2
 Etoposide 72
0.271
 -0.0003 0.4708 0.28492 -0.0360 1.3828 0.9925
1.11022302463e-16
MCF10A-GM_2
 Neratinib 72
0.1892
 0.0640 0.3206 0.16280 0.1057 1.5806 0.9845
1.11022302463e-16
MCF10A-GM_2
 Taxol 72
0.0032
 -0.1684 0.7416 0.00371 -0.1410 1.6859 0.9894
1.11022302463e-16
MCF10A-GM_2
 Palbociclib 72
0.6209
 0.1517 0.3099 0.48785 0.0759 0.6830 0.9438
2.22044604925e-16
MCF10A-GM_2
 Trametinib 72
0.0043
 0.1724 0.5805 0.00311 0.1906 1.4400 0.9921
1.11022302463e-16
MCF10A-GM_2
 Vorinostat 72
1.651
 0.0477 0.2433 1.83380 -0.0704 1.2549 0.9958
1.11022302463e-16
MCF10A-GM_3
 Alpelisib 72
12.9167
 0.5328 0.1116 73.65654 -0.8864 0.5858 0.9876
1.11022302463e-16
MCF10A-GM_3
 Dasatinib 72
0.5827
 -0.0566 0.3862 1.12437 -0.2687 0.6544 0.9878
1.11022302463e-16
MCF10A-GM_3
 Etoposide 72
0.2684
 0.0290 0.4530 0.26650 0.0050 1.4125 0.9928
1.11022302463e-16
MCF10A-GM_3
 Neratinib 72
0.1963
 0.0972 0.3122 0.16522 0.1061 1.3819 0.9827
1.11022302463e-16
MCF10A-GM_3
 Taxol 72
0.0031
 -0.1829 0.7472 0.00355 -0.1448 1.8150 0.9882
1.11022302463e-16
MCF10A-GM_3
 Palbociclib 72
0.8312
 0.1260 0.2902 0.65210 0.0722 0.6423 0.9643
1.11022302463e-16
MCF10A-GM_3
 Trametinib 72
0.0044
 0.2025 0.5787 0.00306 0.1899 1.3238 0.9921
1.11022302463e-16
MCF10A-GM_3
 Vorinostat 72
1.5967
 0.0631 0.2351 1.56566 0.0152 1.5718 0.9965
1.11022302463e-16
MCF10A-GM_4
 Alpelisib 72
14.7321
 0.5350 0.1188 119.95795 -1.0000 0.5239 0.9638
1.11022302463e-16
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