LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20362)

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Cell Small Molecule Timepoint GR50 GRmax GR_AOC GEC50 GRinf h_GR r2_GR pval_GR
MCF10A-GM_1
 Trametinib 72
0.0036
 0.1788 0.6024 0.00255 0.1811 1.2634 0.9812
1.11022302463e-16
MCF10A-GM_3
 Trametinib 72
0.0044
 0.2025 0.5787 0.00306 0.1899 1.3238 0.9921
1.11022302463e-16
MCF10A-GM_2
 Trametinib 72
0.0043
 0.1724 0.5805 0.00311 0.1906 1.4400 0.9921
1.11022302463e-16
MCF10A-GM_4
 Trametinib 72
0.0049
 0.1945 0.5715 0.00332 0.1878 1.2052 0.9846
1.11022302463e-16
MCF10A-GM_3
 Taxol 72
0.0031
 -0.1829 0.7472 0.00355 -0.1448 1.8150 0.9882
1.11022302463e-16
MCF10A-GM_6
 Trametinib 72
0.0053
 0.1799 0.5666 0.00355 0.1936 1.2066 0.9871
1.11022302463e-16
MCF10A-GM_7
 Trametinib 72
0.0049
 0.1766 0.5702 0.00356 0.1886 1.4500 0.9957
1.11022302463e-16
MCF10A-GM_1
 Taxol 72
0.0031
 -0.1839 0.7432 0.00360 -0.1412 1.8163 0.9877
1.11022302463e-16
MCF10A-GM_9
 Trametinib 72
0.0052
 0.2232 0.5524 0.00366 0.2093 1.5591 0.9867
1.11022302463e-16
MCF10A-GM_2
 Taxol 72
0.0032
 -0.1684 0.7416 0.00371 -0.1410 1.6859 0.9894
1.11022302463e-16
MCF10A-GM_8
 Trametinib 72
0.0053
 0.2224 0.5595 0.00373 0.2010 1.4325 0.9894
1.11022302463e-16
MCF10A-GM_5
 Trametinib 72
0.0055
 0.1290 0.5670 0.00383 0.1779 1.2083 0.9766
1.11022302463e-16
MCF10A-GM_4
 Taxol 72
0.0035
 -0.1612 0.7179 0.00406 -0.1470 1.7773 0.9895
1.11022302463e-16
MCF10A-GM_5
 Taxol 72
0.0035
 -0.1747 0.7341 0.00408 -0.1521 1.6592 0.9847
1.11022302463e-16
MCF10A-GM_6
 Taxol 72
0.0036
 -0.1585 0.7040 0.00409 -0.1386 1.7468 0.9850
1.11022302463e-16
MCF10A-GM_7
 Taxol 72
0.0042
 -0.1484 0.7164 0.00501 -0.1660 1.6732 0.9838
1.11022302463e-16
MCF10A-GM_8
 Taxol 72
0.0043
 -0.1715 0.7088 0.00525 -0.1769 1.5821 0.9820
1.11022302463e-16
MCF10A-GM_9
 Taxol 72
0.0044
 -0.2005 0.6800 0.00529 -0.1770 1.6339 0.9825
1.11022302463e-15
MCF10A-GM_1
 Neratinib 72
0.1689
 0.0559 0.3305 0.14681 0.0997 1.5846 0.9862
1.11022302463e-16
MCF10A-GM_2
 Neratinib 72
0.1892
 0.0640 0.3206 0.16280 0.1057 1.5806 0.9845
1.11022302463e-16
MCF10A-GM_3
 Neratinib 72
0.1963
 0.0972 0.3122 0.16522 0.1061 1.3819 0.9827
1.11022302463e-16
MCF10A-GM_1
 Etoposide 72
0.2477
 0.0271 0.4660 0.24946 -0.0050 1.4185 0.9937
1.11022302463e-16
MCF10A-GM_4
 Neratinib 72
0.3213
 0.0948 0.2421 0.25816 0.1783 2.0143 0.9600
4.4408920985e-16
MCF10A-GM_3
 Etoposide 72
0.2684
 0.0290 0.4530 0.26650 0.0050 1.4125 0.9928
1.11022302463e-16
MCF10A-GM_6
 Etoposide 72
0.2852
 0.0349 0.4444 0.28112 0.0099 1.3701 0.9933
1.11022302463e-16
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