LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20362)
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| Cell | Small Molecule | Timepoint | GR50 | GRmax | GR_AOC | GEC50 | GRinf | h_GR | r2_GR | pval_GR |
|---|---|---|---|---|---|---|---|---|---|---|
MCF10A-GM_5 | Alpelisib | 72 | 12.6322 | 0.5207 | 0.1108 | 81.30890 | -1.0000 | 0.5900 | 0.9846 | 1.11022302463e-16 |
MCF10A-GM_4 | Alpelisib | 72 | 14.7321 | 0.5350 | 0.1188 | 119.95795 | -1.0000 | 0.5239 | 0.9638 | 1.11022302463e-16 |
MCF10A-GM_8 | Alpelisib | 72 | 17.8393 | 0.5275 | 0.0998 | 138.06189 | -1.0000 | 0.5369 | 0.9510 | 3.88578058619e-15 |
MCF10A-GM_6 | Alpelisib | 72 | 13.6674 | 0.5343 | 0.1095 | 92.70681 | -1.0000 | 0.5739 | 0.9770 | 1.11022302463e-16 |
MCF10A-GM_3 | Alpelisib | 72 | 12.9167 | 0.5328 | 0.1116 | 73.65654 | -0.8864 | 0.5858 | 0.9876 | 1.11022302463e-16 |
MCF10A-GM_8 | Dasatinib | 72 | 0.7613 | -0.0880 | 0.3632 | 2.43718 | -0.4869 | 0.5844 | 0.9823 | 1.11022302463e-16 |
MCF10A-GM_5 | Dasatinib | 72 | 0.6795 | -0.0849 | 0.3753 | 1.79909 | -0.3886 | 0.5905 | 0.9862 | 1.11022302463e-16 |
MCF10A-GM_9 | Dasatinib | 72 | 0.8384 | -0.0654 | 0.3421 | 1.94935 | -0.3664 | 0.6515 | 0.9807 | 1.11022302463e-16 |
MCF10A-GM_7 | Dasatinib | 72 | 0.7106 | -0.0667 | 0.3612 | 1.65872 | -0.3419 | 0.6146 | 0.9852 | 1.11022302463e-16 |
MCF10A-GM_4 | Dasatinib | 72 | 0.5549 | -0.0532 | 0.3996 | 1.34090 | -0.3371 | 0.5842 | 0.9860 | 1.11022302463e-16 |
MCF10A-GM_6 | Dasatinib | 72 | 0.6238 | -0.0558 | 0.3803 | 1.40075 | -0.3286 | 0.6244 | 0.9838 | 1.11022302463e-16 |
MCF10A-GM_3 | Dasatinib | 72 | 0.5827 | -0.0566 | 0.3862 | 1.12437 | -0.2687 | 0.6544 | 0.9878 | 1.11022302463e-16 |
MCF10A-GM_2 | Dasatinib | 72 | 0.5372 | -0.0593 | 0.3896 | 1.05022 | -0.2667 | 0.6377 | 0.9780 | 1.11022302463e-16 |
MCF10A-GM_1 | Dasatinib | 72 | 0.4799 | -0.0596 | 0.4113 | 0.84280 | -0.2282 | 0.6676 | 0.9832 | 1.11022302463e-16 |
MCF10A-GM_9 | Taxol | 72 | 0.0044 | -0.2005 | 0.6800 | 0.00529 | -0.1770 | 1.6339 | 0.9825 | 1.11022302463e-15 |
MCF10A-GM_8 | Taxol | 72 | 0.0043 | -0.1715 | 0.7088 | 0.00525 | -0.1769 | 1.5821 | 0.9820 | 1.11022302463e-16 |
MCF10A-GM_7 | Taxol | 72 | 0.0042 | -0.1484 | 0.7164 | 0.00501 | -0.1660 | 1.6732 | 0.9838 | 1.11022302463e-16 |
MCF10A-GM_5 | Taxol | 72 | 0.0035 | -0.1747 | 0.7341 | 0.00408 | -0.1521 | 1.6592 | 0.9847 | 1.11022302463e-16 |
MCF10A-GM_4 | Taxol | 72 | 0.0035 | -0.1612 | 0.7179 | 0.00406 | -0.1470 | 1.7773 | 0.9895 | 1.11022302463e-16 |
MCF10A-GM_3 | Taxol | 72 | 0.0031 | -0.1829 | 0.7472 | 0.00355 | -0.1448 | 1.8150 | 0.9882 | 1.11022302463e-16 |
MCF10A-GM_1 | Taxol | 72 | 0.0031 | -0.1839 | 0.7432 | 0.00360 | -0.1412 | 1.8163 | 0.9877 | 1.11022302463e-16 |
MCF10A-GM_2 | Taxol | 72 | 0.0032 | -0.1684 | 0.7416 | 0.00371 | -0.1410 | 1.6859 | 0.9894 | 1.11022302463e-16 |
MCF10A-GM_6 | Taxol | 72 | 0.0036 | -0.1585 | 0.7040 | 0.00409 | -0.1386 | 1.7468 | 0.9850 | 1.11022302463e-16 |
MCF10A-GM_2 | Vorinostat | 72 | 1.651 | 0.0477 | 0.2433 | 1.83380 | -0.0704 | 1.2549 | 0.9958 | 1.11022302463e-16 |
MCF10A-GM_9 | Vorinostat | 72 | 2.5965 | 0.1036 | 0.1840 | 2.74842 | -0.0412 | 1.3907 | 0.9875 | 4.86277684786e-14 |