Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| CAL-120 | SHP099 | 13.63352074 | 0.7924 | 0.0042 | 16.9837 | -1.0000 | 5.0000 | 0.4392 | 0.000724955 |
| HME1 | AZD6738 | 5.825895792 | 0.2920 | 0.0055 | 4.9604 | 0.2763 | 5.0000 | 0.8741 | 5.61e-12 |
| HCC1419 | RO-3306 | 8.899414267 | 0.2237 | 0.0089 | 11.0863 | -1.0000 | 5.0000 | 0.7309 | 7.48e-08 |
| MDA-MB-468 | Ribociclib | inf | 0.7972 | 0.0091 | 0.0000 | 0.9779 | 0.0100 | 0.0000 | 1.0 |
| BT-549 | Ribociclib | inf | 0.9258 | 0.0097 | 0.0000 | 0.9885 | 0.0100 | 0.0000 | 0.489440623384 |
| MDA-MB-436 | GSK2334470 | 26.4830237 | 0.7307 | 0.0123 | 64.9192 | -0.9964 | 1.2226 | 0.3331 | 0.006324926 |
| BT-20 | SHP099 | inf | 0.8790 | 0.0132 | 0.0000 | 0.9876 | 0.0100 | 0.0000 | 0.0930371400466 |
| HCC1428 | RO-3306 | 3.430055795 | -0.4441 | 0.0143 | 3.8909 | -0.2512 | 3.2292 | 0.3585 | 0.003891828 |
| MCF 10A | SHP099 | 13.33532157 | 0.6599 | 0.0155 | 20.0345 | -1.0000 | 2.6990 | 0.8458 | 7.1e-11 |
| MDA-MB-453 | SHP099 | 11.54207272 | 0.7015 | 0.0178 | 14.3805 | -1.0000 | 4.9966 | 0.3055 | 0.010499523 |
| HCC1806 | GSK2334470 | 44.5159354048 | 0.8389 | 0.0198 | 86.1125 | -0.5419 | 1.1127 | 0.3134 | 0.00908806432112 |
| CAL-51 | SHP099 | inf | 0.8600 | 0.0220 | 0.0000 | 0.9665 | 0.0100 | 0.0000 | 1.0 |
| HCC1143 | AZD6738 | 5.179476247 | -0.0433 | 0.0238 | 8.9090 | -0.8835 | 1.8765 | 0.9171 | 3.01e-14 |
| AU565 | SHP099 | inf | 0.9751 | 0.0242 | 0.0000 | 0.9633 | 0.0100 | 0.0000 | 1.0 |
| CAL-120 | RO-3306 | 8.527233934 | 0.1534 | 0.0250 | 10.6226 | -1.0000 | 5.0000 | 0.9423 | 3.33e-16 |
| SK-BR-3 | SHP099 | inf | 0.9987 | 0.0260 | 0.0000 | 0.9879 | 0.0100 | 0.0000 | 1.0 |
| CAL-120 | AZD5363 | 51.38789856 | 0.7988 | 0.0266 | 243.4579 | -1.0000 | 0.7063 | 0.4791 | 0.0002881 |
| MCF 10A | GSK2334470 | 127.2855112 | 0.8292 | 0.0271 | 886.4613 | -0.9671 | 0.5546 | 0.7883 | 3.72e-09 |
| BT-549 | SHP099 | 2619.73295091 | 0.8306 | 0.0279 | 21.5161 | 0.4877 | 0.7710 | 0.6498 | 2.01339374906e-06 |
| MCF 10A | Senexin B | 617.6674136 | 0.8672 | 0.0282 | 1000.0000 | -0.1291 | 0.4768 | 0.7287 | 8.28e-08 |
| MCF7 | SHP099 | inf | 0.8331 | 0.0289 | 0.0000 | 0.9643 | 0.0100 | 0.0000 | 0.073472433 |
| MCF 10A | AZD5363 | 61.7286667806 | 0.7916 | 0.0307 | 77.1806 | -0.0911 | 0.7489 | 0.9088 | 9.96980276113e-14 |
| MCF 10A | AZD6738 | 9.21613673637 | 0.4291 | 0.0314 | 16.0807 | -0.9996 | 1.9730 | 0.9840 | 1.11022302463e-16 |
| MDA-MB-468 | AZD6738 | 10.56189758 | 0.4777 | 0.0335 | 23.3227 | -0.9834 | 1.3728 | 0.7330 | 6.79e-08 |
| CAL-51 | GSK2334470 | 22.73047392 | 0.8334 | 0.0336 | 53.5738 | -0.9998 | 1.2813 | 0.2592 | 0.023515658 |