Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)

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Cell Small Molecule GR50 GRmax GR_AOC GEC50 GRinf GR Hill Coefficient GR r2 pval_GR
MCF 10A Ribociclib
21.11238563
 0.4876 0.1616 1000.0000 -1.0000 0.2848 0.8863
1.58e-12
MCF 10A Senexin B
617.6674136
 0.8672 0.0282 1000.0000 -0.1291 0.4768 0.7287
8.28e-08
Hs 578T Ribociclib
2.691890869
 0.3645 0.3425 1000.0000 -0.7904 0.1602 0.9056
1.53e-13
HME1 Rucaparib
inf
 0.7189 0.1295 1000.0000 0.4363 0.1448 0.3705
0.003075156
Hs 578T Rucaparib
478.5688189
 0.6723 0.1013 1000.0000 -0.1130 0.2766 0.5974
1.15e-05
HCC1143 SHP099
1449.842823
 0.7869 0.0529 1000.0000 0.0556 0.3172 0.3933
0.001935462
Hs 578T Senexin B
2420179.078
 0.7716 0.1355 1000.0000 0.3393 0.1457 0.6302
3.97e-06
Hs 578T SHP099
222.1051901
 0.5953 0.1451 1000.0000 -0.2087 0.2319 0.7318
7.17e-08
HCC38 Rucaparib
3274.321387
 0.6293 0.1296 1000.0000 0.1004 0.1890 0.3579
0.003936714
HCC1937 Senexin B
5.024951315
 0.4311 0.2642 1000.0000 -0.9063 0.1954 0.7116
1.77e-07
HME1 AZD5363
28.44450868
 0.5695 0.1924 1000.0000 -0.6875 0.2430 0.8264
3.11e-10
CAL-51 Senexin B
49184874.89
 0.7426 0.1286 1000.0000 0.4054 0.1541 0.2466
0.029016792
CAL-85-1 Rucaparib
15.9069887
 0.3496 0.2765 1000.0000 -0.6758 0.2065 0.3127
0.009204617
CAL-120 Rucaparib
76.53871191
 0.5903 0.1235 1000.0000 -0.5462 0.2873 0.7153
1.52e-07
CAL-51 AZD5363
30.19251597
 0.5818 0.1493 1000.0000 -0.8752 0.2890 0.7869
4.05e-09
HCC38 GSK2334470
362.2276812
 0.7326 0.0411 1000.0000 -0.2309 0.3738 0.3294
0.006774661
HCC1143 AZD5363
904.4573761
 0.7083 0.0803 1000.0000 -0.0144 0.2833 0.5816
1.86e-05
HCC1395 Ribociclib
3.698589599
 0.3894 0.3243 1000.0000 -0.7936 0.1697 0.6529
1.8e-06
HCC1143 Senexin B
16.15394735
 0.4142 0.1852 1000.0000 -0.7697 0.2259 0.6559
1.62e-06
CAL-120 BMS-265246
2.125230074
 0.3446 0.3401 1000.0000 -0.9133 0.1688 0.8479
6e-11
HCC1143 GSK2334470
438.6004495
 0.6788 0.0824 1000.0000 -0.1385 0.2967 0.5027
0.000161396
CAL-51 Rucaparib
435.2054467
 0.6520 0.0837 1000.0000 -0.1445 0.3052 0.5584
3.65e-05
CAL-120 GSK2334470
4306.150401
 0.7693 0.0812 1000.0000 0.1525 0.2492 0.4548
0.000509344
MDA-MB-436 LY3023414
4.691952741
 0.1749 0.3897 1000.0000 -0.3698 0.1033 0.4098
0.001372738
MCF7 Senexin B
13.10460323
 0.4652 0.2569 1000.0000 -0.6830 0.1987 0.6278
4.31e-06
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