Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| AU565 | BMS-265246 | 0.295937858 | -0.1432 | 0.5304 | 0.7056 | -0.3746 | 0.6436 | 0.6685 | 1.01e-06 |
| AU565 | Ribociclib | 0.595293001 | 0.2313 | 0.4319 | 179.3835 | -0.8827 | 0.1782 | 0.7890 | 3.57e-09 |
| AU565 | Ulixertinib | 10.84540185 | 0.5262 | 0.0915 | 39.9318 | -1.0000 | 0.8429 | 0.6917 | 4.1e-07 |
| AU565 | RO-3306 | 0.451155856 | -0.1943 | 0.4065 | 23.6830 | -1.0000 | 0.2774 | 0.5910 | 1.4e-05 |
| AU565 | AZD2014 | 0.003613668 | 0.0045 | 0.7508 | 0.0061 | -0.0974 | 0.3356 | 0.9277 | 5.44e-15 |
| AU565 | Alvocidib | 0.087632457 | -0.5502 | 0.3751 | 0.2006 | -0.8064 | 1.1595 | 0.9601 | 1.11e-16 |
| AU565 | AZD6738 | 9.117192222 | 0.2755 | 0.0564 | 11.3576 | -1.0000 | 5.0000 | 0.7383 | 5.27e-08 |
| AU565 | MK 1775 | 0.223405816 | -0.4543 | 0.4894 | 3.6482 | -1.0000 | 0.3933 | 0.8692 | 9.09e-12 |
| AU565 | AZD5363 | 5.62582806 | 0.3226 | 0.2242 | 182.9894 | -1.0000 | 0.3155 | 0.7817 | 5.48e-09 |
| AU565 | Rucaparib | inf | 0.6448 | 0.1041 | 0.0000 | 0.9100 | 0.0100 | 0.0000 | 0.204759045 |
| AU565 | LY3023414 | 0.003983539 | -0.4704 | 0.7921 | 0.8999 | -1.0000 | 0.2027 | 0.8707 | 7.87e-12 |
| AU565 | Senexin B | inf | 0.8184 | 0.1417 | 0.0000 | 0.8787 | 0.0100 | 0.0000 | 0.163234872 |
| AU565 | SHP099 | inf | 0.9751 | 0.0242 | 0.0000 | 0.9633 | 0.0100 | 0.0000 | 1.0 |
| AU565 | THZ1 | 0.018314242 | -0.5809 | 0.5779 | 0.0306 | -0.5110 | 1.3730 | 0.9728 | 1.11e-16 |
| AU565 | THZ531 | 0.054699066 | -0.4980 | 0.4261 | 0.0769 | -0.4380 | 1.8479 | 0.9799 | 1.11e-16 |
| AU565 | GSK2334470 | 7.667010215 | 0.3822 | 0.2226 | 556.8242 | -1.0000 | 0.2564 | 0.7005 | 2.86e-07 |
| BT-20 | MK 1775 | 1.80498033053 | -0.6583 | 0.2015 | 4.1869 | -1.0000 | 1.3057 | 0.9322 | 2.44249065418e-15 |
| BT-20 | Ulixertinib | 11.8069404762 | 0.3655 | 0.1384 | 160.1062 | -1.0000 | 0.4214 | 0.7256 | 9.53864038866e-08 |
| BT-20 | Alvocidib | 0.109020751309 | -0.6023 | 0.3436 | 0.2983 | -1.0000 | 1.0915 | 0.9859 | 1.11022302463e-16 |
| BT-20 | AZD2014 | 0.129099948542 | 0.1187 | 0.4911 | 0.6794 | -0.2850 | 0.2716 | 0.8667 | 1.14693810005e-11 |
| BT-20 | AZD5363 | 1.72900360981 | 0.1717 | 0.3013 | 86.6237 | -1.0000 | 0.2807 | 0.8604 | 2.05393480002e-11 |
| BT-20 | AZD6738 | 5.68190940846 | 0.1069 | -0.0571 | 5.4098 | 0.1088 | 5.0000 | 0.8298 | 2.43821740575e-10 |
| BT-20 | BMS-265246 | 0.0017956253308 | -0.0805 | 0.8520 | 0.0041 | -0.1756 | 0.3616 | 0.9532 | 1.11022302463e-16 |
| BT-20 | Ribociclib | 0.364051568488 | 0.0541 | 0.4406 | 65.2706 | -1.0000 | 0.2117 | 0.8623 | 1.72427627732e-11 |
| BT-20 | GSK2334470 | 13.6041849907 | 0.6953 | 0.0817 | 27.5398 | -0.9501 | 1.5098 | 0.3727 | 0.00293794501251 |