Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | THZ1 | 0.014309421 | -0.7784 | 0.6625 | 0.0292 | -0.7395 | 1.2733 | 0.9657 | 1.11e-16 |
| SUM159PT | THZ1 | 0.365558748 | -0.1398 | 0.1554 | 0.8540 | -1.0000 | 1.2947 | 0.9765 | 1.11e-16 |
| MCF7 | THZ1 | 0.022830734 | -0.4455 | 0.4917 | 0.0384 | -0.4128 | 1.1568 | 0.9820 | 1.11e-16 |
| MCF7 | THZ531 | 0.061536132 | -0.3360 | 0.3371 | 0.0797 | -0.2528 | 1.5809 | 0.9654 | 1.11e-16 |
| MCF 10A | Alvocidib | 0.099467899 | -0.4802 | 0.3475 | 0.1398 | -0.5288 | 2.1178 | 0.9920 | 1.11e-16 |
| MDA-MB-468 | Alvocidib | 0.173077952 | -0.4235 | 0.2942 | 0.4622 | -0.9850 | 1.1084 | 0.9659 | 1.11e-16 |
| CAL-51 | Alvocidib | 0.203450964 | -0.1017 | 0.2311 | 0.8363 | -1.0000 | 0.7772 | 0.9758 | 1.11e-16 |
| MDA-MB-157 | THZ1 | 0.032181836 | -0.8998 | 0.5842 | 0.0485 | -0.8227 | 2.3777 | 0.9766 | 1.11e-16 |
| CAL-51 | AZD6738 | 5.499126795 | 0.0467 | 0.0977 | 10.8204 | -1.0000 | 1.6231 | 0.9631 | 1.11e-16 |
| T47D | THZ1 | 0.02898118 | -0.2718 | 0.4598 | 0.0353 | -0.2278 | 1.8920 | 0.9732 | 1.11e-16 |
| MDA-MB-453 | THZ1 | 0.01132408 | -0.3194 | 0.5368 | 0.0145 | -0.2023 | 1.3641 | 0.9524 | 1.11e-16 |
| SUM149PT | THZ531 | 0.351886206 | -0.4909 | 0.1494 | 0.5549 | -0.8336 | 2.1536 | 0.9830 | 1.11e-16 |
| CAL-120 | MK 1775 | 0.196043462 | -0.2603 | 0.4877 | 0.9132 | -0.5740 | 0.4969 | 0.9800 | 1.11e-16 |
| SUM149PT | THZ1 | 0.048963473 | -0.4879 | 0.4000 | 0.0794 | -0.4676 | 1.3644 | 0.9885 | 1.11e-16 |
| CAL-51 | MK 1775 | 0.310910353 | -0.1886 | 0.4395 | 4.9452 | -1.0000 | 0.3971 | 0.9792 | 1.11e-16 |
| AU565 | THZ531 | 0.054699066 | -0.4980 | 0.4261 | 0.0769 | -0.4380 | 1.8479 | 0.9799 | 1.11e-16 |
| HCC1419 | THZ531 | 0.159567693 | -0.3116 | 0.2249 | 0.1946 | -0.3196 | 2.4891 | 0.9564 | 1.11e-16 |
| CAL-120 | THZ531 | 0.148031898 | -0.0605 | 0.1979 | 0.1679 | -0.0944 | 1.3725 | 0.9703 | 1.11e-16 |
| HCC1954 | LY3023414 | 0.000261242275613 | -0.4250 | 0.8272 | 1.0238 | -1.0000 | 0.1328 | 0.7220 | 1.12126955498e-07 |
| BT-20 | AZD2014 | 0.129099948542 | 0.1187 | 0.4911 | 0.6794 | -0.2850 | 0.2716 | 0.8667 | 1.14693810005e-11 |
| Hs 578T | Rucaparib | 478.5688189 | 0.6723 | 0.1013 | 1000.0000 | -0.1130 | 0.2766 | 0.5974 | 1.15e-05 |
| HCC1937 | Alvocidib | 0.166518918 | -0.2096 | 0.2105 | 0.2327 | -0.3409 | 1.5542 | 0.9076 | 1.17e-13 |
| MDA-MB-453 | AZD6738 | 4.833057791 | -0.1286 | 0.1011 | 8.9747 | -1.0000 | 1.7750 | 0.9231 | 1.19e-14 |
| MDA-MB-453 | BMS-265246 | 0.757165765 | 0.2593 | 0.3794 | 214.7431 | -1.0000 | 0.1945 | 0.7673 | 1.21e-08 |
| MDA-MB-361 | Alvocidib | 0.089713792 | -0.4956 | 0.4193 | 0.3494 | -1.0000 | 0.8080 | 0.8065 | 1.21e-09 |