Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HME1 | LY3023414 | 0.00281434 | 0.0335 | 0.6767 | 41.9336 | -1.0000 | 0.1143 | 0.9275 | 5.66e-15 |
| HCC1143 | Ulixertinib | 1.718095034 | 0.0344 | 0.2458 | 19.1869 | -1.0000 | 0.4553 | 0.8884 | 1.25e-12 |
| MDA-MB-134-VI | RO-3306 | -inf | 0.0360 | ||||||
| MDA-MB-453 | RO-3306 | 5.832801693 | 0.0432 | 0.0980 | 10.4904 | -1.0000 | 1.8717 | 0.8565 | 2.89e-11 |
| CAL-51 | AZD6738 | 5.499126795 | 0.0467 | 0.0977 | 10.8204 | -1.0000 | 1.6231 | 0.9631 | 1.11e-16 |
| MCF 10A | LY3023414 | 0.157364650671 | 0.0496 | 0.4399 | 0.1188 | 0.0589 | 0.4459 | 0.9485 | 1.11022302463e-16 |
| MDA-MB-361 | Ulixertinib | 0.487697861 | 0.0501 | 0.2106 | 0.3084 | 0.4494 | 5.0000 | 0.6060 | 8.79e-06 |
| MCF7 | AZD6738 | 3.087754601 | 0.0508 | 0.1795 | 12.4507 | -1.0000 | 0.7879 | 0.9144 | 4.54e-14 |
| BT-20 | Ribociclib | 0.364051568488 | 0.0541 | 0.4406 | 65.2706 | -1.0000 | 0.2117 | 0.8623 | 1.72427627732e-11 |
| HME1 | BMS-265246 | 0.001224504 | 0.0652 | 0.8579 | 0.0014 | -0.0301 | 0.4949 | 0.9271 | 6.11e-15 |
| MDA-MB-361 | RO-3306 | 5.850186547 | 0.0653 | 0.1084 | 11.6847 | -1.0000 | 1.5880 | 0.6865 | 5.05e-07 |
| T47D | Ribociclib | -inf | 0.0709 | ||||||
| MCF 10A | BMS-265246 | 0.304944263 | 0.0710 | 0.4137 | 6.3855 | -0.7513 | 0.3016 | 0.9516 | 1.11e-16 |
| MCF7 | BMS-265246 | 0.007863864 | 0.0723 | 0.6940 | 0.0070 | 0.0264 | 0.4576 | 0.9598 | 1.11e-16 |
| SUM149PT | BMS-265246 | 0.016950371 | 0.0738 | 0.6317 | 0.0171 | -0.0015 | 0.3767 | 0.9526 | 1.11e-16 |
| MCF 10A | AZD2014 | 0.432150800137 | 0.0828 | 0.4111 | 4.6296 | -0.4698 | 0.2793 | 0.9640 | 1.11022302463e-16 |
| SUM1315MO2 | AZD2014 | 0.001390649 | 0.0852 | 0.6690 | 6.8904 | -0.6708 | 0.1000 | 0.3997 | 0.001697935 |
| MCF7 | RO-3306 | 6.254157687 | 0.0869 | 0.0697 | 10.7929 | -1.0000 | 2.0134 | 0.8978 | 4.13e-13 |
| MDA-MB-231 | RO-3306 | 8.57955379445 | 0.0936 | -0.0084 | 10.6878 | -1.0000 | 5.0000 | 0.9180 | 2.64233079861e-14 |
| BT-20 | Senexin B | 2.23064370113 | 0.0956 | 0.2772 | 71.2131 | -1.0000 | 0.3172 | 0.7918 | 3.02648173189e-09 |
| T47D | MK 1775 | 5.03699179 | 0.0963 | 0.1055 | 14.4307 | -1.0000 | 1.0438 | 0.8167 | 6.18e-10 |
| SUM159PT | AZD2014 | 0.175359057 | 0.0970 | 0.4747 | 4.2801 | -0.5797 | 0.2409 | 0.9735 | 1.11e-16 |
| CAL-51 | THZ1 | 0.398213883 | 0.0975 | 0.1363 | 1.3472 | -1.0000 | 0.9014 | 0.9402 | 5.55e-16 |
| SUM159PT | RO-3306 | 7.498110755 | 0.1030 | 0.0581 | 11.0876 | -1.0000 | 2.8085 | 0.9796 | 1.11e-16 |
| BT-20 | AZD6738 | 5.68190940846 | 0.1069 | -0.0571 | 5.4098 | 0.1088 | 5.0000 | 0.8298 | 2.43821740575e-10 |