Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| CAL-85-1 | AZD6738 | 6.237645512 | 0.1470 | 0.1766 | 11.7933 | -1.0000 | 1.7249 | 0.5594 | 3.56e-05 |
| CAL-85-1 | BMS-265246 | 0.006551436 | -0.0684 | 0.7136 | 8.4904 | -1.0000 | 0.1533 | 0.7672 | 1.22e-08 |
| CAL-85-1 | Ulixertinib | 3.83746694 | 0.2311 | 0.2960 | 72.1557 | -1.0000 | 0.3744 | 0.3008 | 0.011412092 |
| CAL-120 | RO-3306 | 8.527233934 | 0.1534 | 0.0250 | 10.6226 | -1.0000 | 5.0000 | 0.9423 | 3.33e-16 |
| AU565 | AZD5363 | 5.62582806 | 0.3226 | 0.2242 | 182.9894 | -1.0000 | 0.3155 | 0.7817 | 5.48e-09 |
| CAL-120 | AZD5363 | 51.38789856 | 0.7988 | 0.0266 | 243.4579 | -1.0000 | 0.7063 | 0.4791 | 0.0002881 |
| HCC1143 | Ulixertinib | 1.718095034 | 0.0344 | 0.2458 | 19.1869 | -1.0000 | 0.4553 | 0.8884 | 1.25e-12 |
| CAL-85-1 | RO-3306 | 6.045627864 | -0.3140 | 0.2213 | 9.4578 | -1.0000 | 2.4550 | 0.5125 | 0.000125886 |
| CAL-120 | SHP099 | 13.63352074 | 0.7924 | 0.0042 | 16.9837 | -1.0000 | 5.0000 | 0.4392 | 0.000724955 |
| HCC1428 | MK 1775 | 4.367124658 | -0.4009 | 0.1027 | 7.4399 | -1.0000 | 2.0621 | 0.4706 | 0.000352941 |
| HCC1143 | AZD2014 | 0.421624866 | 0.1334 | 0.3982 | 59.1681 | -1.0000 | 0.2222 | 0.9449 | 2.22e-16 |
| HCC1143 | Ribociclib | 3.643695147 | 0.3009 | 0.2535 | 264.9902 | -1.0000 | 0.2563 | 0.8300 | 2.41e-10 |
| AU565 | GSK2334470 | 7.667010215 | 0.3822 | 0.2226 | 556.8242 | -1.0000 | 0.2564 | 0.7005 | 2.86e-07 |
| CAMA-1 | MK 1775 | 5.412146559 | -0.2519 | 0.0565 | 8.5802 | -1.0000 | 2.3841 | 0.7821 | 5.36e-09 |
| CAL-51 | MK 1775 | 0.310910353 | -0.1886 | 0.4395 | 4.9452 | -1.0000 | 0.3971 | 0.9792 | 1.11e-16 |
| CAMA-1 | AZD5363 | 0.048497519 | -0.1534 | 0.5494 | 10.8262 | -1.0000 | 0.2031 | 0.8383 | 1.28e-10 |
| CAMA-1 | AZD6738 | 8.908669378 | 0.2804 | -0.0237 | 11.1124 | -1.0000 | 4.9704 | 0.6787 | 6.86e-07 |
| CAL-51 | AZD2014 | 0.186060272 | 0.1980 | 0.4693 | 322.5046 | -1.0000 | 0.1473 | 0.9177 | 2.79e-14 |
| CAMA-1 | Ulixertinib | 2.566161953 | 0.1288 | 0.2586 | 42.4009 | -1.0000 | 0.3917 | 0.5616 | 3.34e-05 |
| CAMA-1 | Alvocidib | 0.174755194 | -0.1534 | 0.2533 | 0.7555 | -1.0000 | 0.7504 | 0.7392 | 5.05e-08 |
| CAL-51 | AZD6738 | 5.499126795 | 0.0467 | 0.0977 | 10.8204 | -1.0000 | 1.6231 | 0.9631 | 1.11e-16 |
| AU565 | AZD6738 | 9.117192222 | 0.2755 | 0.0564 | 11.3576 | -1.0000 | 5.0000 | 0.7383 | 5.27e-08 |
| CAL-51 | BMS-265246 | 4.166699159 | 0.3180 | 0.2124 | 83.7459 | -1.0000 | 0.3661 | 0.8327 | 1.96e-10 |
| MCF 10A | THZ531 | 0.403782298 | -0.4375 | 0.1475 | 0.6623 | -1.0000 | 2.2199 | 0.9948 | 1.11e-16 |
| MCF 10A | SHP099 | 13.33532157 | 0.6599 | 0.0155 | 20.0345 | -1.0000 | 2.6990 | 0.8458 | 7.1e-11 |