Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| CAL-120 | RO-3306 | 8.527233934 | 0.1534 | 0.0250 | 10.6226 | -1.0000 | 5.0000 | 0.9423 | 3.33e-16 |
| AU565 | AZD5363 | 5.62582806 | 0.3226 | 0.2242 | 182.9894 | -1.0000 | 0.3155 | 0.7817 | 5.48e-09 |
| HCC1143 | AZD2014 | 0.421624866 | 0.1334 | 0.3982 | 59.1681 | -1.0000 | 0.2222 | 0.9449 | 2.22e-16 |
| CAL-120 | SHP099 | 13.63352074 | 0.7924 | 0.0042 | 16.9837 | -1.0000 | 5.0000 | 0.4392 | 0.000724955 |
| CAMA-1 | Alvocidib | 0.174755194 | -0.1534 | 0.2533 | 0.7555 | -1.0000 | 0.7504 | 0.7392 | 5.05e-08 |
| AU565 | GSK2334470 | 7.667010215 | 0.3822 | 0.2226 | 556.8242 | -1.0000 | 0.2564 | 0.7005 | 2.86e-07 |
| CAL-51 | MK 1775 | 0.310910353 | -0.1886 | 0.4395 | 4.9452 | -1.0000 | 0.3971 | 0.9792 | 1.11e-16 |
| CAL-51 | AZD2014 | 0.186060272 | 0.1980 | 0.4693 | 322.5046 | -1.0000 | 0.1473 | 0.9177 | 2.79e-14 |
| CAMA-1 | Senexin B | 1.06482186 | 0.2022 | 0.3355 | 175.6924 | -1.0000 | 0.2152 | 0.5567 | 3.84e-05 |
| CAL-51 | AZD6738 | 5.499126795 | 0.0467 | 0.0977 | 10.8204 | -1.0000 | 1.6231 | 0.9631 | 1.11e-16 |
| CAL-51 | BMS-265246 | 4.166699159 | 0.3180 | 0.2124 | 83.7459 | -1.0000 | 0.3661 | 0.8327 | 1.96e-10 |
| CAL-120 | AZD5363 | 51.38789856 | 0.7988 | 0.0266 | 243.4579 | -1.0000 | 0.7063 | 0.4791 | 0.0002881 |
| CAL-51 | Alvocidib | 0.203450964 | -0.1017 | 0.2311 | 0.8363 | -1.0000 | 0.7772 | 0.9758 | 1.11e-16 |
| AU565 | LY3023414 | 0.003983539 | -0.4704 | 0.7921 | 0.8999 | -1.0000 | 0.2027 | 0.8707 | 7.87e-12 |
| CAL-51 | Ribociclib | 3.77803891 | 0.3496 | 0.2868 | 766.6836 | -1.0000 | 0.2068 | 0.9334 | 2e-15 |
| CAL-51 | LY3023414 | 0.012387901 | -0.1180 | 0.6129 | 29.3234 | -1.0000 | 0.1414 | 0.7984 | 2.03e-09 |
| CAL-51 | RO-3306 | 8.346101408 | 0.1772 | 0.0379 | 11.9039 | -1.0000 | 3.0941 | 0.9243 | 9.77e-15 |
| CAL-120 | Ulixertinib | 9.575963441 | 0.4271 | 0.1000 | 64.2469 | -1.0000 | 0.5772 | 0.9125 | 5.95e-14 |
| CAL-85-1 | BMS-265246 | 0.006551436 | -0.0684 | 0.7136 | 8.4904 | -1.0000 | 0.1533 | 0.7672 | 1.22e-08 |
| AU565 | RO-3306 | 0.451155856 | -0.1943 | 0.4065 | 23.6830 | -1.0000 | 0.2774 | 0.5910 | 1.4e-05 |
| CAL-51 | THZ1 | 0.398213883 | 0.0975 | 0.1363 | 1.3472 | -1.0000 | 0.9014 | 0.9402 | 5.55e-16 |
| AU565 | Ulixertinib | 10.84540185 | 0.5262 | 0.0915 | 39.9318 | -1.0000 | 0.8429 | 0.6917 | 4.1e-07 |
| CAL-85-1 | MK 1775 | 0.182874423 | -0.5298 | 0.5409 | 3.0854 | -1.0000 | 0.3888 | 0.7205 | 1.2e-07 |
| HCC1428 | Rucaparib | 0.023670881 | -0.2500 | 0.7420 | 7.6534 | -1.0000 | 0.1901 | 0.2290 | 0.038773048 |
| HCC1428 | LY3023414 | 4.66e-07 | -0.7374 | 1.2208 | 0.0032 | -1.0000 | 0.1242 | 0.3630 | 0.003559188 |