Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC38 | LY3023414 | 0.003293109 | -0.0192 | 0.6632 | 57.0896 | -0.9609 | 0.1099 | 0.8238 | 3.77e-10 |
| HME1 | AZD5363 | 28.44450868 | 0.5695 | 0.1924 | 1000.0000 | -0.6875 | 0.2430 | 0.8264 | 3.11e-10 |
| MDA-MB-453 | Ribociclib | 0.036110625 | 0.1975 | 0.5328 | 0.0251 | 0.0538 | 0.3126 | 0.8276 | 2.86e-10 |
| SK-BR-3 | RO-3306 | 4.923330764 | -0.0769 | 0.1282 | 9.5682 | -1.0000 | 1.6534 | 0.8284 | 2.7e-10 |
| BT-20 | AZD6738 | 5.68190940846 | 0.1069 | -0.0571 | 5.4098 | 0.1088 | 5.0000 | 0.8298 | 2.43821740575e-10 |
| HCC1143 | Ribociclib | 3.643695147 | 0.3009 | 0.2535 | 264.9902 | -1.0000 | 0.2563 | 0.8300 | 2.41e-10 |
| MDA-MB-436 | BMS-265246 | 1.037326297 | 0.1940 | 0.3751 | 107.0431 | -1.0000 | 0.2369 | 0.8308 | 2.26e-10 |
| MDA-MB-436 | MK 1775 | 0.189831078 | -0.2473 | 0.4933 | 6.7449 | -1.0000 | 0.3077 | 0.8316 | 2.13e-10 |
| CAL-51 | BMS-265246 | 4.166699159 | 0.3180 | 0.2124 | 83.7459 | -1.0000 | 0.3661 | 0.8327 | 1.96e-10 |
| HCC1419 | AZD2014 | 0.000451019 | -0.1328 | 0.9581 | 0.0009 | -0.1553 | 0.4080 | 0.8343 | 1.75e-10 |
| CAMA-1 | AZD5363 | 0.048497519 | -0.1534 | 0.5494 | 10.8262 | -1.0000 | 0.2031 | 0.8383 | 1.28e-10 |
| HCC70 | AZD2014 | 0.000212092429893 | 0.0222 | 0.7748 | 0.0025 | -0.2340 | 0.1552 | 0.8423 | 9.37158128878e-11 |
| SUM1315MO2 | LY3023414 | 0.016412717 | -0.2854 | 0.6641 | 4.0058 | -1.0000 | 0.1998 | 0.8425 | 9.21e-11 |
| MCF7 | Ribociclib | 0.189284804 | 0.2285 | 0.4067 | 0.0345 | 0.2453 | 0.3959 | 0.8429 | 8.95e-11 |
| MCF 10A | SHP099 | 13.33532157 | 0.6599 | 0.0155 | 20.0345 | -1.0000 | 2.6990 | 0.8458 | 7.1e-11 |
| MDA-MB-231 | AZD6738 | 8.82761747838 | 0.3448 | -0.0384 | 12.4996 | -0.9998 | 3.1583 | 0.8459 | 7.04556413211e-11 |
| HCC38 | Ribociclib | 0.517768611 | 0.2321 | 0.4237 | 305.2273 | -1.0000 | 0.1722 | 0.8460 | 6.98e-11 |
| HCC1937 | BMS-265246 | 0.000340758 | -0.0634 | 0.9143 | 0.0005 | -0.0734 | 0.4108 | 0.8462 | 6.89e-11 |
| HCC70 | Ulixertinib | 1.412958526 | 0.3819 | 0.2819 | 0.0475 | 0.4787 | 0.9295 | 0.8473 | 6.27075058546e-11 |
| CAL-120 | BMS-265246 | 2.125230074 | 0.3446 | 0.3401 | 1000.0000 | -0.9133 | 0.1688 | 0.8479 | 6e-11 |
| T47D | RO-3306 | 7.208767727 | -0.0474 | 0.1168 | 9.9142 | -1.0000 | 3.4475 | 0.8495 | 5.24e-11 |
| SUM159PT | Ribociclib | 9.362543456 | 0.3950 | 0.2403 | 1000.0000 | -0.9311 | 0.2251 | 0.8497 | 5.16e-11 |
| SUM149PT | AZD5363 | 6.721919624 | 0.3022 | 0.1227 | 30.2610 | -1.0000 | 0.7302 | 0.8514 | 4.46e-11 |
| HCC1954 | AZD6738 | 5.21852308366 | 0.1138 | -0.0199 | 5.0338 | 0.0824 | 5.0000 | 0.8519 | 4.27073931775e-11 |
| Hs 578T | LY3023414 | 0.000331352 | 0.0271 | 0.6875 | 0.1184 | -0.4001 | 0.1000 | 0.8522 | 4.17e-11 |