Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MCF7 | THZ1 | 0.022830734 | -0.4455 | 0.4917 | 0.0384 | -0.4128 | 1.1568 | 0.9820 | 1.11e-16 |
| HCC1806 | RO-3306 | 5.34198338119 | -0.1128 | 0.0801 | 5.6376 | -0.1545 | 5.0000 | 0.9818 | 1.11022302463e-16 |
| HCC38 | MK 1775 | 0.004188304 | -0.4069 | 0.9360 | 0.0178 | -0.4523 | 0.4447 | 0.9813 | 1.11e-16 |
| HCC1806 | AZD6738 | 1.14078689634 | -0.2827 | 0.2797 | 3.6562 | -0.8273 | 0.8382 | 0.9812 | 1.11022302463e-16 |
| CAL-120 | MK 1775 | 0.196043462 | -0.2603 | 0.4877 | 0.9132 | -0.5740 | 0.4969 | 0.9800 | 1.11e-16 |
| AU565 | THZ531 | 0.054699066 | -0.4980 | 0.4261 | 0.0769 | -0.4380 | 1.8479 | 0.9799 | 1.11e-16 |
| SUM159PT | RO-3306 | 7.498110755 | 0.1030 | 0.0581 | 11.0876 | -1.0000 | 2.8085 | 0.9796 | 1.11e-16 |
| CAL-51 | MK 1775 | 0.310910353 | -0.1886 | 0.4395 | 4.9452 | -1.0000 | 0.3971 | 0.9792 | 1.11e-16 |
| MCF 10A | RO-3306 | 5.73070119167 | -0.1356 | 0.1173 | 9.4363 | -1.0000 | 2.2028 | 0.9791 | 1.11022302463e-16 |
| SUM149PT | Alvocidib | 0.194050461 | -0.4382 | 0.2360 | 0.3478 | -0.7138 | 1.5198 | 0.9775 | 1.11e-16 |
| MDA-MB-157 | THZ1 | 0.032181836 | -0.8998 | 0.5842 | 0.0485 | -0.8227 | 2.3777 | 0.9766 | 1.11e-16 |
| MDA-MB-231 | Alvocidib | 0.135898926115 | -0.3881 | 0.2892 | 0.4189 | -0.9657 | 0.9554 | 0.9765 | 1.11022302463e-16 |
| SUM159PT | THZ1 | 0.365558748 | -0.1398 | 0.1554 | 0.8540 | -1.0000 | 1.2947 | 0.9765 | 1.11e-16 |
| HCC1954 | THZ1 | 0.0965224052209 | -0.5246 | 0.2985 | 0.1858 | -0.6687 | 1.2967 | 0.9764 | 1.11022302463e-16 |
| HME1 | THZ531 | 0.22121156 | -0.1882 | 0.1768 | 0.2567 | -0.2330 | 2.5689 | 0.9759 | 1.11e-16 |
| CAL-51 | Alvocidib | 0.203450964 | -0.1017 | 0.2311 | 0.8363 | -1.0000 | 0.7772 | 0.9758 | 1.11e-16 |
| Hs 578T | AZD6738 | 5.182870146 | -0.0390 | 0.0818 | 10.0001 | -1.0000 | 1.6716 | 0.9755 | 1.11e-16 |
| Hs 578T | RO-3306 | 4.300129294 | -0.0976 | 0.1258 | 9.7624 | -1.0000 | 1.3399 | 0.9749 | 1.11e-16 |
| HCC38 | Alvocidib | 0.139603749 | -0.4046 | 0.2799 | 0.3955 | -0.9001 | 0.9887 | 0.9746 | 1.11e-16 |
| Hs 578T | MK 1775 | 0.014507078 | -0.3462 | 0.7648 | 0.0762 | -0.4564 | 0.3909 | 0.9740 | 1.11e-16 |
| MCF 10A | MK 1775 | 6.09709750724 | 0.0219 | 0.0882 | 10.8200 | -1.0000 | 1.9153 | 0.9738 | 1.11022302463e-16 |
| SUM159PT | AZD2014 | 0.175359057 | 0.0970 | 0.4747 | 4.2801 | -0.5797 | 0.2409 | 0.9735 | 1.11e-16 |
| BT-20 | THZ1 | 0.497469085347 | -0.4365 | 0.0947 | 0.7408 | -1.0000 | 2.7590 | 0.9734 | 1.11022302463e-16 |
| MDA-MB-231 | THZ531 | 0.237593052092 | -0.2649 | 0.2086 | 0.6335 | -1.0000 | 1.1202 | 0.9732 | 1.11022302463e-16 |
| T47D | THZ1 | 0.02898118 | -0.2718 | 0.4598 | 0.0353 | -0.2278 | 1.8920 | 0.9732 | 1.11e-16 |