Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1143 Topotecan
Topo I
Chemotherapy
0.0094142
 -0.4304 0.9040 0.3002 1.1711
0.013874
0.94725
HCC1954 INK-128
mTORC1/2
PI3K/mTOR
0.014251
 -0.0830 0.5651 0.1455 1.3479
0.013876
0.98856
BT-549 Dinaciclib
pan CDK
Cell cycle
0.012371
 -0.2923 0.5913 0.1485 3.7837
0.013904
0.99899
PDX1258 Doxorubicin
Chemo
Chemotherapy
0.0091389
 -0.4928 0.7540 0.2368 1.1844
0.013938
0.97567
MDA-MB-453 AZD7762
CHK1/2
Cell cycle
0.011509
 -0.2157 0.8564 0.1405 1.6714
0.014102
0.99393
HCC70 Doxorubicin
Chemo
Chemotherapy
0.010621
 -0.7794 0.7867 0.1459 2.0410
0.014138
0.93856
SUM149PT Volasertib
PLK
Cell cycle
0.011968
 -0.3041 0.5727 0.2215 2.4715
0.014187
0.99692
CAL-51 Doxorubicin
Chemo
Chemotherapy
0.0085841
 -0.4803 0.7954 0.2347 1.0881
0.014188
0.98761
PDX1258 Dinaciclib
pan CDK
Cell cycle
0.011566
 -0.6173 0.7036 0.2838 3.5943
0.014366
0.99779
MCF7 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0083619
 -0.2545 0.7677 0.1823 0.5107
0.014367
0.95432
SUM159PT INK-128
mTORC1/2
PI3K/mTOR
0.018735
 0.1504 0.4832 0.0004 1.5649
0.014424
0.99839
MDA-MB-361 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0050713
 -0.9642 0.8689 0.2561 0.9911
0.014575
0.99687
BT-549 INK-128
mTORC1/2
PI3K/mTOR
0.016573
 0.0717 0.5339 0.0484 1.5295
0.014683
0.99934
PDX1328 Dinaciclib
pan CDK
Cell cycle
0.011496
 -0.7107 0.7519 0.2292 3.5560
0.014708
0.9982
HCC38 Dinaciclib
pan CDK
Cell cycle
0.012678
 -0.4422 0.6326 0.2241 4.1199
0.014763
0.99821
MDA-MB-436 Dinaciclib
pan CDK
Cell cycle
0.014324
 -0.1440 0.4903 0.0235 4.8527
0.014993
0.99777
MDA-MB-231 INK-128
mTORC1/2
PI3K/mTOR
0.021834
 0.1013 0.4860 0.0253 1.0516
0.015209
0.98917
HCC1954 Dinaciclib
pan CDK
Cell cycle
0.012538
 -0.4640 0.6411 0.3049 3.3292
0.015238
0.99808
PDXHCI002 Topotecan
Topo I
Chemotherapy
0.0066461
 -0.7006 1.0199 0.1157 0.8130
0.015555
0.94766
HCC1395 Dinaciclib
pan CDK
Cell cycle
0.012405
 -0.4966 0.6520 0.1554 2.9854
0.015612
0.99791
HCC38 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.01047
 -0.2107 0.5383 0.0927 0.8737
0.015621
0.99367
HCC1395 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.014555
 -0.1424 0.4547 0.0604 1.6344
0.015746
0.98865
HCC70 Dinaciclib
pan CDK
Cell cycle
0.01286
 -0.9093 0.8338 0.3254 5.0000
0.015807
0.9991
MDA-MB-468 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.016032
 -0.0415 0.4371 0.1010 0.9482
0.015849
0.98843
MDA-MB-134-VI Dinaciclib
pan CDK
Cell cycle
0.010529
 -0.8440 0.7452 0.1522 2.1701
0.015963
0.99365