Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAL-51 Neratinib
EGFR/HER2
RTK
2.2484
 0.2802 0.0910 0.0109 1.5163
4.6402
0.98601
CAL-85-1 Alpelisib
PI3Ka
PI3K/mTOR
3.6425
 0.2928 0.1938 0.0110 0.4506
41.7026
0.9641
HCC1143 ABT-737
Bcl2/XL
Misc
6.1992
 0.3758 0.1027 0.0110 0.8672
8.5825
0.98522
HME1 Palbociclib
CDK4/6
Cell cycle
0.22285
 0.2572 0.2611 0.0111 0.9777
0.10881
0.98803
T47D Ipatasertib
AKT
PI3K/mTOR
0.13653
 0.1331 0.4303 0.0112 1.0853
0.10541
0.99474
PDX1258 Olaparib
PARP
Misc
11.9912
 0.5770 0.0287 0.0113 1.2287
29.2905
0.94883
MCF7 Trametinib
MEK
MAPK/nRTK
Inf
 0.5581 0.2767 0.0114 1.2083
0.0027903
0.99413
SK-BR-3 Cisplatin
Chemo
Chemotherapy
5.1075
 0.2490 0.0978 0.0114 1.4151
5.7965
0.99044
MDA-MB-157 Alpelisib
PI3Ka
PI3K/mTOR
9.7515
 0.4924 0.1041 0.0114 0.6775
11.4208
0.96993
MCF7 ABT-737
Bcl2/XL
Misc
22.5968
 0.7267 0.0146 0.0115 1.1080
29.1513
0.88699
MDA-MB-468 Cabozantinib
VEGFR2/MET
RTK
8.9681
 0.4233 0.0441 0.0115 1.7711
16.6732
0.9812
SUM1315MO2 Palbociclib
CDK4/6
Cell cycle
0.093193
 0.3001 0.3314 0.0115 0.9738
0.030153
0.98295
MDA-MB-436 Ipatasertib
AKT
PI3K/mTOR
25.8679
 0.6111 0.1038 0.0116 0.4073
383.9431
0.92516
HCC1500 Alpelisib
PI3Ka
PI3K/mTOR
12.7881
 0.5807 0.0302 0.0118 1.1251
18.7215
0.91512
MDA-MB-157 Saracatinib
SRC
MAPK/nRTK
5.2322
 0.3548 0.1697 0.0119 0.4524
59.3534
0.96508
MDA-MB-231 Pictilisib
pan PI3K
PI3K/mTOR
5.3159
 0.3053 0.2062 0.0120 0.3649
107.9707
0.87205
PDX1258 Ipatasertib
AKT
PI3K/mTOR
4.4024
 0.3985 0.1556 0.0120 0.7553
1.2185
0.94717
HCC70 A-1210477
Mcl-1
Misc
Inf
 0.9380 0.0054 0.0123 0.0000
Inf
0.17964
HCC1419 Cediranib
VEGFR/cKIT
RTK
5.0599
 -0.0329 0.0545 0.0124 4.9952
5.1984
0.99032
MDA-MB-436 Pictilisib
pan PI3K
PI3K/mTOR
5.2741
 0.2850 0.1328 0.0124 0.7767
21.6999
0.98441
CAL-51 Trametinib
MEK
MAPK/nRTK
Inf
 0.7064 0.0662 0.0124 0.8944
0.19105
0.98439
HCC1395 TGX221
PI3Kb
PI3K/mTOR
8.4625
 0.4581 0.0950 0.0125 0.6815
16.0341
0.94431
SUM149PT Abemaciclib
CDK4/6
Cell cycle
0.6361
 0.0949 0.3411 0.0126 0.4432
1.358
0.96302
HCC1419 Saracatinib
SRC
MAPK/nRTK
0.91888
 -0.1146 0.2758 0.0128 0.8021
1.8388
0.98394
HCC1500 Cabozantinib
VEGFR2/MET
RTK
4.6683
 0.1837 0.0599 0.0128 4.9992
4.2912
0.97044