Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SK-BR-3 Taselisib
1.0
PI3Ka, g, d
PI3K/mTOR
 -0.0011 0.19707
SK-BR-3 Taselisib
3.1623
PI3Ka, g, d
PI3K/mTOR
 -0.0551 0.21381
SK-BR-3 Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 -0.2068 0.28829
SK-BR-3 TGX221
0.001
PI3Kb
PI3K/mTOR
 1.0131 -0.00077
SK-BR-3 TGX221
0.0031623
PI3Kb
PI3K/mTOR
 1.0490 -0.00162
SK-BR-3 TGX221
0.01
PI3Kb
PI3K/mTOR
 1.0825 -0.00261
SK-BR-3 TGX221
0.031623
PI3Kb
PI3K/mTOR
 1.0421 -0.00164
SK-BR-3 TGX221
0.1
PI3Kb
PI3K/mTOR
 1.0459 0.00620
SK-BR-3 TGX221
0.31623
PI3Kb
PI3K/mTOR
 1.0213 0.00645
SK-BR-3 TGX221
1.0
PI3Kb
PI3K/mTOR
 1.0206 0.01441
SK-BR-3 TGX221
3.1623
PI3Kb
PI3K/mTOR
 0.9571 0.00329
SK-BR-3 TGX221
10.0
PI3Kb
PI3K/mTOR
 0.7496 0.04446
SK-BR-3 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0099 0.00868
SK-BR-3 Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 1.0226 0.00153
SK-BR-3 Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 0.8670 0.02137
SK-BR-3 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.5556 0.06307
SK-BR-3 Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.0548 0.18046
SK-BR-3 Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 -0.1665 0.26149
SK-BR-3 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 -0.2481 0.32792
SK-BR-3 Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 -0.2897 0.33442
SK-BR-3 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.3416 0.37655
SK-BR-3 Everolimus
0.001
mTOR1
PI3K/mTOR
 0.2858 0.11936
SK-BR-3 Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.2478 0.10454
SK-BR-3 Everolimus
0.01
mTOR1
PI3K/mTOR
 0.2555 0.12068
SK-BR-3 Everolimus
0.031623
mTOR1
PI3K/mTOR
 0.2095 0.13143