Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SK-BR-3 Everolimus
0.1
mTOR1
PI3K/mTOR
 0.1795 0.11167
SK-BR-3 Everolimus
0.31623
mTOR1
PI3K/mTOR
 0.2007 0.11281
SK-BR-3 Everolimus
1.0
mTOR1
PI3K/mTOR
 0.2001 0.12531
SK-BR-3 Everolimus
3.1623
mTOR1
PI3K/mTOR
 0.1494 0.11709
SK-BR-3 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.1182 0.14493
SK-BR-3 INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 0.9181 0.00327
SK-BR-3 INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.7797 0.02296
SK-BR-3 INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 0.4668 0.08693
SK-BR-3 INK-128
0.01
mTORC1/2
PI3K/mTOR
 -0.0376 0.21190
SK-BR-3 INK-128
0.031623
mTORC1/2
PI3K/mTOR
 -0.2218 0.32008
SK-BR-3 INK-128
0.1
mTORC1/2
PI3K/mTOR
 -0.2787 0.37272
SK-BR-3 INK-128
0.31623
mTORC1/2
PI3K/mTOR
 -0.3157 0.40520
SK-BR-3 INK-128
1.0
mTORC1/2
PI3K/mTOR
 -0.3684 0.45002
SK-BR-3 INK-128
3.1623
mTORC1/2
PI3K/mTOR
 -0.5064 0.55021
SK-BR-3 PF-4708671
0.001
p70S6K
PI3K/mTOR
 1.0653 0.00100
SK-BR-3 PF-4708671
0.0031623
p70S6K
PI3K/mTOR
 1.0248 0.00633
SK-BR-3 PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.0426 -0.00125
SK-BR-3 PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0506 -0.00055
SK-BR-3 PF-4708671
0.1
p70S6K
PI3K/mTOR
 0.9936 0.00085
SK-BR-3 PF-4708671
0.31623
p70S6K
PI3K/mTOR
 0.9860 0.00444
SK-BR-3 PF-4708671
1.0
p70S6K
PI3K/mTOR
 0.9613 -0.00473
SK-BR-3 PF-4708671
3.1623
p70S6K
PI3K/mTOR
 0.8782 0.00499
SK-BR-3 PF-4708671
10.0
p70S6K
PI3K/mTOR
 0.7342 0.03936
SK-BR-3 Buparlisib
0.001
pan PI3K
PI3K/mTOR
 0.9656 0.00033
SK-BR-3 Buparlisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9476 0.00498