Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MDA-MB-231 Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.2351 0.29310
MDA-MB-231 Pictilisib
0.001
pan PI3K
PI3K/mTOR
 0.9197 0.00509
MDA-MB-231 Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9438 0.00332
MDA-MB-231 Pictilisib
0.01
pan PI3K
PI3K/mTOR
 0.8987 0.00884
MDA-MB-231 Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.8334 0.00455
MDA-MB-231 Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.8216 0.01056
MDA-MB-231 Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.8073 0.00434
MDA-MB-231 Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.7442 0.00758
MDA-MB-231 Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.6891 0.00403
MDA-MB-231 Pictilisib
10.0
pan PI3K
PI3K/mTOR
 0.3053 0.05995
MDA-MB-231 Ceritinib
0.001
ALK
RTK
 0.9817 -0.00460
MDA-MB-231 Ceritinib
0.0031623
ALK
RTK
 1.0038 0.00182
MDA-MB-231 Ceritinib
0.01
ALK
RTK
 0.9448 0.00067
MDA-MB-231 Ceritinib
0.031623
ALK
RTK
 0.9641 0.00244
MDA-MB-231 Ceritinib
0.1
ALK
RTK
 0.9345 0.00742
MDA-MB-231 Ceritinib
0.31623
ALK
RTK
 0.8699 0.00705
MDA-MB-231 Ceritinib
1.0
ALK
RTK
 0.4315 0.05064
MDA-MB-231 Ceritinib
3.1623
ALK
RTK
 -0.2283 0.32154
MDA-MB-231 Ceritinib
10.0
ALK
RTK
 -0.3326 0.52556
MDA-MB-231 Neratinib
0.00031623
EGFR/HER2
RTK
 0.9892 0.00060
MDA-MB-231 Neratinib
0.001
EGFR/HER2
RTK
 1.0081 0.00055
MDA-MB-231 Neratinib
0.0031623
EGFR/HER2
RTK
 0.9869 0.00434
MDA-MB-231 Neratinib
0.01
EGFR/HER2
RTK
 1.0537 0.00088
MDA-MB-231 Neratinib
0.031623
EGFR/HER2
RTK
 1.0276 0.01086
MDA-MB-231 Neratinib
0.1
EGFR/HER2
RTK
 1.0215 0.00735