Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MDA-MB-231 INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.9192 0.00192
MDA-MB-231 INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 0.8914 -0.00298
MDA-MB-231 INK-128
0.01
mTORC1/2
PI3K/mTOR
 0.6769 0.00924
MDA-MB-231 INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.4100 0.02957
MDA-MB-231 INK-128
0.1
mTORC1/2
PI3K/mTOR
 0.2534 0.04087
MDA-MB-231 INK-128
0.31623
mTORC1/2
PI3K/mTOR
 0.2047 0.03614
MDA-MB-231 INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.2275 0.04031
MDA-MB-231 INK-128
3.1623
mTORC1/2
PI3K/mTOR
 0.1013 0.07065
MDA-MB-231 PF-4708671
0.001
p70S6K
PI3K/mTOR
 0.9914 0.00595
MDA-MB-231 PF-4708671
0.0031623
p70S6K
PI3K/mTOR
 0.9931 0.01060
MDA-MB-231 PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.0232 0.00510
MDA-MB-231 PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0077 -0.00197
MDA-MB-231 PF-4708671
0.1
p70S6K
PI3K/mTOR
 1.0375 0.00174
MDA-MB-231 PF-4708671
0.31623
p70S6K
PI3K/mTOR
 0.9745 0.00499
MDA-MB-231 PF-4708671
1.0
p70S6K
PI3K/mTOR
 1.0013 0.00801
MDA-MB-231 PF-4708671
3.1623
p70S6K
PI3K/mTOR
 0.9555 0.00987
MDA-MB-231 PF-4708671
10.0
p70S6K
PI3K/mTOR
 0.8544 0.01688
MDA-MB-231 Buparlisib
0.001
pan PI3K
PI3K/mTOR
 0.9241 0.00198
MDA-MB-231 Buparlisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9868 0.00054
MDA-MB-231 Buparlisib
0.01
pan PI3K
PI3K/mTOR
 0.8981 0.00925
MDA-MB-231 Buparlisib
0.031623
pan PI3K
PI3K/mTOR
 0.9463 0.00352
MDA-MB-231 Buparlisib
0.1
pan PI3K
PI3K/mTOR
 0.9232 0.01273
MDA-MB-231 Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 0.9171 0.00118
MDA-MB-231 Buparlisib
1.0
pan PI3K
PI3K/mTOR
 0.7384 0.01989
MDA-MB-231 Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 0.0452 0.19387