Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MDA-MB-231 TGX221
0.031623
PI3Kb
PI3K/mTOR
 1.0151 0.00626
MDA-MB-231 TGX221
0.1
PI3Kb
PI3K/mTOR
 0.9459 0.01509
MDA-MB-231 TGX221
0.31623
PI3Kb
PI3K/mTOR
 1.0007 0.00057
MDA-MB-231 TGX221
1.0
PI3Kb
PI3K/mTOR
 0.9256 0.00385
MDA-MB-231 TGX221
3.1623
PI3Kb
PI3K/mTOR
 0.9391 0.00782
MDA-MB-231 TGX221
10.0
PI3Kb
PI3K/mTOR
 0.8508 0.01781
MDA-MB-231 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0116 0.00659
MDA-MB-231 Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9887 0.00258
MDA-MB-231 Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 1.0068 0.00242
MDA-MB-231 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9218 0.00252
MDA-MB-231 Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.7027 0.01092
MDA-MB-231 Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.4120 0.02786
MDA-MB-231 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.2244 0.06226
MDA-MB-231 Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 0.1663 0.07742
MDA-MB-231 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.0262 0.23744
MDA-MB-231 Everolimus
0.001
mTOR1
PI3K/mTOR
 0.8133 0.00226
MDA-MB-231 Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.8744 -0.00534
MDA-MB-231 Everolimus
0.01
mTOR1
PI3K/mTOR
 0.7718 -0.00357
MDA-MB-231 Everolimus
0.031623
mTOR1
PI3K/mTOR
 0.7551 -0.00159
MDA-MB-231 Everolimus
0.1
mTOR1
PI3K/mTOR
 0.7402 -0.00514
MDA-MB-231 Everolimus
0.31623
mTOR1
PI3K/mTOR
 0.7678 0.00220
MDA-MB-231 Everolimus
1.0
mTOR1
PI3K/mTOR
 0.7575 -0.00003
MDA-MB-231 Everolimus
3.1623
mTOR1
PI3K/mTOR
 0.7748 -0.00021
MDA-MB-231 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.7110 0.00581
MDA-MB-231 INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 0.9572 0.00181