Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF7 Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.3101 0.06510
MCF7 Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.1653 0.14092
MCF7 Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.0129 0.23438
MCF7 Pictilisib
10.0
pan PI3K
PI3K/mTOR
 -0.1594 0.41522
MCF7 Ceritinib
0.001
ALK
RTK
 1.0019 0.00045
MCF7 Ceritinib
0.0031623
ALK
RTK
 1.0478 0.00101
MCF7 Ceritinib
0.01
ALK
RTK
 0.9923 0.00275
MCF7 Ceritinib
0.031623
ALK
RTK
 0.9756 0.00574
MCF7 Ceritinib
0.1
ALK
RTK
 0.8293 0.01447
MCF7 Ceritinib
0.31623
ALK
RTK
 0.5120 0.03603
MCF7 Ceritinib
1.0
ALK
RTK
 0.0289 0.16654
MCF7 Ceritinib
3.1623
ALK
RTK
 -0.2319 0.34888
MCF7 Ceritinib
10.0
ALK
RTK
 -0.6157 0.76213
MCF7 Neratinib
0.00031623
EGFR/HER2
RTK
 1.0421 -0.00005
MCF7 Neratinib
0.001
EGFR/HER2
RTK
 1.0169 0.00311
MCF7 Neratinib
0.0031623
EGFR/HER2
RTK
 1.0100 0.00134
MCF7 Neratinib
0.01
EGFR/HER2
RTK
 0.9698 0.00282
MCF7 Neratinib
0.031623
EGFR/HER2
RTK
 0.9574 0.00296
MCF7 Neratinib
0.1
EGFR/HER2
RTK
 0.9226 0.00258
MCF7 Neratinib
0.31623
EGFR/HER2
RTK
 0.7702 0.00891
MCF7 Neratinib
1.0
EGFR/HER2
RTK
 0.6665 0.01254
MCF7 Neratinib
3.1623
EGFR/HER2
RTK
 0.0582 0.16366
MCF7 Tivantinib
0.001
MET
RTK
 1.0116 0.00123
MCF7 Tivantinib
0.0031623
MET
RTK
 1.0089 0.00155
MCF7 Tivantinib
0.01
MET
RTK
 1.0276 0.00024