Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Abemaciclib | 0.0031623 | CDK4/6 | Cell cycle | 0.8583 | 0.00282 |
| MDA-MB-231 | Abemaciclib | 0.01 | CDK4/6 | Cell cycle | 0.7012 | -0.00059 |
| MDA-MB-231 | Abemaciclib | 0.031623 | CDK4/6 | Cell cycle | 0.4981 | 0.00329 |
| MDA-MB-231 | Abemaciclib | 0.1 | CDK4/6 | Cell cycle | 0.2911 | 0.03747 |
| MDA-MB-231 | Abemaciclib | 0.31623 | CDK4/6 | Cell cycle | 0.1512 | 0.05085 |
| MDA-MB-231 | Abemaciclib | 1.0 | CDK4/6 | Cell cycle | 0.0712 | 0.11638 |
| MDA-MB-231 | Abemaciclib | 3.1623 | CDK4/6 | Cell cycle | -0.1904 | 0.37030 |
| MDA-MB-231 | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.4875 | 0.66697 |
| MDA-MB-231 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 1.0771 | 0.00134 |
| MDA-MB-231 | Palbociclib | 0.001 | CDK4/6 | Cell cycle | 0.9933 | 0.00405 |
| MDA-MB-231 | Palbociclib | 0.0031623 | CDK4/6 | Cell cycle | 0.9194 | -0.00272 |
| MDA-MB-231 | Palbociclib | 0.01 | CDK4/6 | Cell cycle | 0.8221 | -0.00579 |
| MDA-MB-231 | Palbociclib | 0.031623 | CDK4/6 | Cell cycle | 0.6564 | -0.00354 |
| MDA-MB-231 | Palbociclib | 0.1 | CDK4/6 | Cell cycle | 0.5015 | 0.00933 |
| MDA-MB-231 | Palbociclib | 0.31623 | CDK4/6 | Cell cycle | 0.4172 | 0.01567 |
| MDA-MB-231 | Palbociclib | 1.0 | CDK4/6 | Cell cycle | 0.2865 | 0.03314 |
| MDA-MB-231 | Palbociclib | 3.1623 | CDK4/6 | Cell cycle | 0.2066 | 0.03980 |
| MDA-MB-231 | AZD7762 | 0.001 | CHK1/2 | Cell cycle | 1.0672 | 0.00807 |
| MDA-MB-231 | AZD7762 | 0.0031623 | CHK1/2 | Cell cycle | 1.0685 | 0.00985 |
| MDA-MB-231 | AZD7762 | 0.01 | CHK1/2 | Cell cycle | 1.1122 | 0.02829 |
| MDA-MB-231 | AZD7762 | 0.031623 | CHK1/2 | Cell cycle | 0.9306 | 0.06651 |
| MDA-MB-231 | AZD7762 | 0.1 | CHK1/2 | Cell cycle | 0.5084 | 0.18185 |
| MDA-MB-231 | AZD7762 | 0.31623 | CHK1/2 | Cell cycle | 0.2822 | 0.24126 |
| MDA-MB-231 | AZD7762 | 1.0 | CHK1/2 | Cell cycle | -0.0553 | 0.35599 |
| MDA-MB-231 | AZD7762 | 3.1623 | CHK1/2 | Cell cycle | -0.3630 | 0.59853 |