Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MDA-MB-231 AZD7762
10.0
CHK1/2
Cell cycle
 -0.4632 0.68964
MDA-MB-231 Volasertib
0.0001
PLK
Cell cycle
 1.0247 0.00180
MDA-MB-231 Volasertib
0.00031623
PLK
Cell cycle
 1.0754 -0.00092
MDA-MB-231 Volasertib
0.001
PLK
Cell cycle
 1.0286 -0.00390
MDA-MB-231 Volasertib
0.0031623
PLK
Cell cycle
 0.7618 0.02847
MDA-MB-231 Volasertib
0.01
PLK
Cell cycle
 0.0321 0.22457
MDA-MB-231 Volasertib
0.031623
PLK
Cell cycle
 -0.0356 0.29799
MDA-MB-231 Volasertib
0.1
PLK
Cell cycle
 -0.0206 0.29493
MDA-MB-231 Volasertib
0.31623
PLK
Cell cycle
 -0.0177 0.24514
MDA-MB-231 Volasertib
1.0
PLK
Cell cycle
 -0.0186 0.13531
MDA-MB-231 Dinaciclib
0.0001
pan CDK
Cell cycle
 0.9345 0.00720
MDA-MB-231 Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.0243 0.00209
MDA-MB-231 Dinaciclib
0.001
pan CDK
Cell cycle
 0.9617 0.00541
MDA-MB-231 Dinaciclib
0.0031623
pan CDK
Cell cycle
 0.9347 -0.00315
MDA-MB-231 Dinaciclib
0.01
pan CDK
Cell cycle
 0.5305 0.05582
MDA-MB-231 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.2901 0.46501
MDA-MB-231 Dinaciclib
0.1
pan CDK
Cell cycle
 -0.3532 0.56698
MDA-MB-231 Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.3669 0.58629
MDA-MB-231 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.4203 0.61381
MDA-MB-231 Cisplatin
0.0010833
Chemo
Chemotherapy
 1.0167 -0.00312
MDA-MB-231 Cisplatin
0.0033333
Chemo
Chemotherapy
 1.0090 0.00249
MDA-MB-231 Cisplatin
0.01
Chemo
Chemotherapy
 1.0091 -0.00247
MDA-MB-231 Cisplatin
0.031667
Chemo
Chemotherapy
 1.0066 -0.00139
MDA-MB-231 Cisplatin
0.1
Chemo
Chemotherapy
 0.9825 -0.00214
MDA-MB-231 Cisplatin
0.31623
Chemo
Chemotherapy
 0.9613 -0.00068