Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF7 Abemaciclib
3.1623
CDK4/6
Cell cycle
 -0.1849 0.28178
MCF7 Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.2684 0.37106
MCF7 Palbociclib
0.00031623
CDK4/6
Cell cycle
 1.0497 -0.00053
MCF7 Palbociclib
0.001
CDK4/6
Cell cycle
 1.0148 -0.00035
MCF7 Palbociclib
0.0031623
CDK4/6
Cell cycle
 0.9626 0.00110
MCF7 Palbociclib
0.01
CDK4/6
Cell cycle
 0.8482 0.00569
MCF7 Palbociclib
0.031623
CDK4/6
Cell cycle
 0.6284 0.00999
MCF7 Palbociclib
0.1
CDK4/6
Cell cycle
 0.4771 0.02002
MCF7 Palbociclib
0.31623
CDK4/6
Cell cycle
 0.3498 0.02137
MCF7 Palbociclib
1.0
CDK4/6
Cell cycle
 0.2988 0.03512
MCF7 Palbociclib
3.1623
CDK4/6
Cell cycle
 0.2542 0.03271
MCF7 AZD7762
0.001
CHK1/2
Cell cycle
 1.0613 0.00059
MCF7 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.0516 0.00377
MCF7 AZD7762
0.01
CHK1/2
Cell cycle
 0.8201 0.03043
MCF7 AZD7762
0.031623
CHK1/2
Cell cycle
 0.4485 0.08317
MCF7 AZD7762
0.1
CHK1/2
Cell cycle
 0.2606 0.12493
MCF7 AZD7762
0.31623
CHK1/2
Cell cycle
 0.2020 0.14115
MCF7 AZD7762
1.0
CHK1/2
Cell cycle
 0.0645 0.19217
MCF7 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.0593 0.24287
MCF7 AZD7762
10.0
CHK1/2
Cell cycle
 -0.1856 0.36741
MCF7 Volasertib
0.0001
PLK
Cell cycle
 1.0847 -0.00321
MCF7 Volasertib
0.00031623
PLK
Cell cycle
 1.0510 0.00013
MCF7 Volasertib
0.001
PLK
Cell cycle
 0.9905 0.00586
MCF7 Volasertib
0.0031623
PLK
Cell cycle
 0.4017 0.10378
MCF7 Volasertib
0.01
PLK
Cell cycle
 0.0437 0.24132