Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF7 Volasertib
0.031623
PLK
Cell cycle
 0.0546 0.24395
MCF7 Volasertib
0.1
PLK
Cell cycle
 0.0625 0.21651
MCF7 Volasertib
0.31623
PLK
Cell cycle
 0.0327 0.16201
MCF7 Volasertib
1.0
PLK
Cell cycle
 -0.0338 0.14981
MCF7 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0167 -0.00027
MCF7 Dinaciclib
0.00031623
pan CDK
Cell cycle
 0.9849 0.00004
MCF7 Dinaciclib
0.001
pan CDK
Cell cycle
 0.9930 -0.00030
MCF7 Dinaciclib
0.0031623
pan CDK
Cell cycle
 0.9638 0.00285
MCF7 Dinaciclib
0.01
pan CDK
Cell cycle
 0.2967 0.07764
MCF7 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.2589 0.32613
MCF7 Dinaciclib
0.1
pan CDK
Cell cycle
 -0.2745 0.27166
MCF7 Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.2416 0.22207
MCF7 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.2493 0.23039
MCF7 Cisplatin
0.0010833
Chemo
Chemotherapy
 1.0155 -0.00053
MCF7 Cisplatin
0.0033333
Chemo
Chemotherapy
 1.0038 -0.00028
MCF7 Cisplatin
0.01
Chemo
Chemotherapy
 1.0128 -0.00016
MCF7 Cisplatin
0.031667
Chemo
Chemotherapy
 1.0295 0.00025
MCF7 Cisplatin
0.1
Chemo
Chemotherapy
 1.0003 0.00055
MCF7 Cisplatin
0.31623
Chemo
Chemotherapy
 0.9807 -0.00008
MCF7 Cisplatin
1.0
Chemo
Chemotherapy
 0.9293 -0.00010
MCF7 Cisplatin
3.1623
Chemo
Chemotherapy
 0.7984 -0.00228
MCF7 Cisplatin
10.0
Chemo
Chemotherapy
 0.4749 0.03626
MCF7 Doxorubicin
0.00031623
Chemo
Chemotherapy
 0.9780 0.00219
MCF7 Doxorubicin
0.001
Chemo
Chemotherapy
 1.0236 0.00107
MCF7 Doxorubicin
0.0031623
Chemo
Chemotherapy
 0.9283 0.00565