Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF 10A Etoposide
3.1623
Topo II
Chemotherapy
 -0.0063 0.12244
MCF 10A Etoposide
10.0
Topo II
Chemotherapy
 -0.0699 0.22191
MCF 10A Dasatinib
0.001
BCR/ABL
MAPK/nRTK
 0.9725 0.00203
MCF 10A Dasatinib
0.0031623
BCR/ABL
MAPK/nRTK
 0.9607 0.00078
MCF 10A Dasatinib
0.01
BCR/ABL
MAPK/nRTK
 0.9318 0.00105
MCF 10A Dasatinib
0.031623
BCR/ABL
MAPK/nRTK
 0.8985 0.00471
MCF 10A Dasatinib
0.1
BCR/ABL
MAPK/nRTK
 0.7696 0.00488
MCF 10A Dasatinib
0.31623
BCR/ABL
MAPK/nRTK
 0.5721 0.02684
MCF 10A Dasatinib
1.0
BCR/ABL
MAPK/nRTK
 0.5055 0.05901
MCF 10A Dasatinib
3.1623
BCR/ABL
MAPK/nRTK
 0.1747 0.16395
MCF 10A Dasatinib
10.0
BCR/ABL
MAPK/nRTK
 -0.0146 0.29397
MCF 10A Trametinib
0.0001
MEK
MAPK/nRTK
 0.9875 -0.00048
MCF 10A Trametinib
0.00031623
MEK
MAPK/nRTK
 0.9272 -0.00328
MCF 10A Trametinib
0.001
MEK
MAPK/nRTK
 0.7591 -0.00633
MCF 10A Trametinib
0.0031623
MEK
MAPK/nRTK
 0.5384 -0.00704
MCF 10A Trametinib
0.01
MEK
MAPK/nRTK
 0.2990 -0.00278
MCF 10A Trametinib
0.031623
MEK
MAPK/nRTK
 0.2260 -0.00136
MCF 10A Trametinib
0.1
MEK
MAPK/nRTK
 0.2047 0.00167
MCF 10A Trametinib
0.31623
MEK
MAPK/nRTK
 0.2268 0.00150
MCF 10A Trametinib
1.0
MEK
MAPK/nRTK
 0.2252 0.00446
MCF 10A Saracatinib
0.001
SRC
MAPK/nRTK
 1.0065 -0.00016
MCF 10A Saracatinib
0.0031623
SRC
MAPK/nRTK
 0.9944 0.00064
MCF 10A Saracatinib
0.01
SRC
MAPK/nRTK
 0.9949 -0.00034
MCF 10A Saracatinib
0.031623
SRC
MAPK/nRTK
 0.9830 -0.00203
MCF 10A Saracatinib
0.1
SRC
MAPK/nRTK
 0.9633 -0.00173