Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC1143 Ceritinib
10.0
ALK
RTK
 -0.4219 0.33428
HCC1143 Neratinib
0.00031623
EGFR/HER2
RTK
 0.9592 0.00012
HCC1143 Neratinib
0.001
EGFR/HER2
RTK
 0.9598 -0.00247
HCC1143 Neratinib
0.0031623
EGFR/HER2
RTK
 0.9469 0.00364
HCC1143 Neratinib
0.01
EGFR/HER2
RTK
 0.8775 0.01377
HCC1143 Neratinib
0.031623
EGFR/HER2
RTK
 0.8972 0.01233
HCC1143 Neratinib
0.1
EGFR/HER2
RTK
 0.7692 0.03147
HCC1143 Neratinib
0.31623
EGFR/HER2
RTK
 0.6590 0.04354
HCC1143 Neratinib
1.0
EGFR/HER2
RTK
 0.4678 0.07604
HCC1143 Neratinib
3.1623
EGFR/HER2
RTK
 0.0791 0.26138
HCC1143 Tivantinib
0.001
MET
RTK
 0.9573 0.00374
HCC1143 Tivantinib
0.0031623
MET
RTK
 0.9937 0.00006
HCC1143 Tivantinib
0.01
MET
RTK
 0.9652 0.00199
HCC1143 Tivantinib
0.031623
MET
RTK
 0.9445 0.00943
HCC1143 Tivantinib
0.1
MET
RTK
 0.8265 0.03318
HCC1143 Tivantinib
0.31623
MET
RTK
 0.4668 0.10959
HCC1143 Tivantinib
1.0
MET
RTK
 -0.2130 0.37320
HCC1143 Tivantinib
3.1623
MET
RTK
 -0.3122 0.42191
HCC1143 Tivantinib
10.0
MET
RTK
 -0.2627 0.27889
HCC1143 Cediranib
0.001
VEGFR/cKIT
RTK
 0.9524 0.00166
HCC1143 Cediranib
0.0031623
VEGFR/cKIT
RTK
 0.9631 0.00268
HCC1143 Cediranib
0.01
VEGFR/cKIT
RTK
 0.9771 0.00615
HCC1143 Cediranib
0.031623
VEGFR/cKIT
RTK
 0.9872 0.00369
HCC1143 Cediranib
0.1
VEGFR/cKIT
RTK
 0.9429 0.00598
HCC1143 Cediranib
0.31623
VEGFR/cKIT
RTK
 0.8763 0.01530