Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC1143 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.1413 -0.00545
HCC1143 AZD7762
0.01
CHK1/2
Cell cycle
 1.1802 0.01087
HCC1143 AZD7762
0.031623
CHK1/2
Cell cycle
 0.7560 0.07887
HCC1143 AZD7762
0.1
CHK1/2
Cell cycle
 0.1184 0.27395
HCC1143 AZD7762
0.31623
CHK1/2
Cell cycle
 -0.1008 0.35800
HCC1143 AZD7762
1.0
CHK1/2
Cell cycle
 -0.1975 0.37852
HCC1143 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.2669 0.39191
HCC1143 AZD7762
10.0
CHK1/2
Cell cycle
 -0.3693 0.49106
HCC1143 Volasertib
0.0001
PLK
Cell cycle
 0.9814 -0.00177
HCC1143 Volasertib
0.00031623
PLK
Cell cycle
 1.0114 0.00201
HCC1143 Volasertib
0.001
PLK
Cell cycle
 0.9460 0.01093
HCC1143 Volasertib
0.0031623
PLK
Cell cycle
 0.6953 0.06953
HCC1143 Volasertib
0.01
PLK
Cell cycle
 0.0448 0.25702
HCC1143 Volasertib
0.031623
PLK
Cell cycle
 -0.2409 0.42562
HCC1143 Volasertib
0.1
PLK
Cell cycle
 -0.2909 0.45990
HCC1143 Volasertib
0.31623
PLK
Cell cycle
 -0.3158 0.47501
HCC1143 Volasertib
1.0
PLK
Cell cycle
 -0.3453 0.47835
HCC1143 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0087 -0.00131
HCC1143 Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.0099 -0.00282
HCC1143 Dinaciclib
0.001
pan CDK
Cell cycle
 0.9936 -0.00321
HCC1143 Dinaciclib
0.0031623
pan CDK
Cell cycle
 1.0273 -0.00286
HCC1143 Dinaciclib
0.01
pan CDK
Cell cycle
 0.9208 0.00399
HCC1143 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.2345 0.25175
HCC1143 Dinaciclib
0.1
pan CDK
Cell cycle
 -0.2164 0.25718
HCC1143 Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.2527 0.25167