Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| CAL-85-1 | Cabozantinib | 0.031623 | VEGFR2/MET | RTK | 1.0082 | 0.00016 |
| CAL-85-1 | Cabozantinib | 0.1 | VEGFR2/MET | RTK | 1.0169 | -0.00055 |
| CAL-85-1 | Cabozantinib | 0.31623 | VEGFR2/MET | RTK | 0.8769 | 0.01425 |
| CAL-85-1 | Cabozantinib | 1.0 | VEGFR2/MET | RTK | 0.9066 | 0.01994 |
| CAL-85-1 | Cabozantinib | 3.1623 | VEGFR2/MET | RTK | 0.7204 | 0.02854 |
| CAL-85-1 | Cabozantinib | 10.0 | VEGFR2/MET | RTK | 0.1728 | 0.17862 |
| HCC1143 | Abemaciclib | 0.001 | CDK4/6 | Cell cycle | 0.8938 | -0.00404 |
| HCC1143 | Abemaciclib | 0.0031623 | CDK4/6 | Cell cycle | 0.9193 | -0.00541 |
| HCC1143 | Abemaciclib | 0.01 | CDK4/6 | Cell cycle | 0.7388 | -0.00534 |
| HCC1143 | Abemaciclib | 0.031623 | CDK4/6 | Cell cycle | 0.5957 | -0.00172 |
| HCC1143 | Abemaciclib | 0.1 | CDK4/6 | Cell cycle | 0.4126 | -0.00406 |
| HCC1143 | Abemaciclib | 0.31623 | CDK4/6 | Cell cycle | 0.2761 | -0.00268 |
| HCC1143 | Abemaciclib | 1.0 | CDK4/6 | Cell cycle | 0.1854 | 0.00721 |
| HCC1143 | Abemaciclib | 3.1623 | CDK4/6 | Cell cycle | 0.1385 | 0.02744 |
| HCC1143 | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.0787 | 0.12659 |
| HCC1143 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 0.9935 | 0.00177 |
| HCC1143 | Palbociclib | 0.001 | CDK4/6 | Cell cycle | 1.0079 | 0.00171 |
| HCC1143 | Palbociclib | 0.0031623 | CDK4/6 | Cell cycle | 1.0203 | -0.00461 |
| HCC1143 | Palbociclib | 0.01 | CDK4/6 | Cell cycle | 0.9533 | -0.00651 |
| HCC1143 | Palbociclib | 0.031623 | CDK4/6 | Cell cycle | 0.8032 | -0.00537 |
| HCC1143 | Palbociclib | 0.1 | CDK4/6 | Cell cycle | 0.6432 | -0.00358 |
| HCC1143 | Palbociclib | 0.31623 | CDK4/6 | Cell cycle | 0.4914 | -0.00644 |
| HCC1143 | Palbociclib | 1.0 | CDK4/6 | Cell cycle | 0.4060 | -0.00728 |
| HCC1143 | Palbociclib | 3.1623 | CDK4/6 | Cell cycle | 0.2820 | 0.00028 |
| HCC1143 | AZD7762 | 0.001 | CHK1/2 | Cell cycle | 1.1696 | -0.00494 |