Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
PDXHCI002 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.4925 -0.03840
PDXHCI002 Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 0.2536 0.01337
PDXHCI002 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.1017 0.18967
PDXHCI002 Everolimus
0.001
mTOR1
PI3K/mTOR
 1.1106 -0.04384
PDXHCI002 Everolimus
0.0031623
mTOR1
PI3K/mTOR
 1.0799 -0.04679
PDXHCI002 Everolimus
0.01
mTOR1
PI3K/mTOR
 1.1376 -0.04754
PDXHCI002 Everolimus
0.031623
mTOR1
PI3K/mTOR
 1.1053 -0.04958
PDXHCI002 Everolimus
0.1
mTOR1
PI3K/mTOR
 1.1029 -0.05190
PDXHCI002 Everolimus
0.31623
mTOR1
PI3K/mTOR
 1.1168 -0.05253
PDXHCI002 Everolimus
1.0
mTOR1
PI3K/mTOR
 1.0816 -0.04413
PDXHCI002 Everolimus
3.1623
mTOR1
PI3K/mTOR
 1.0442 -0.04734
PDXHCI002 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.9869 -0.04768
PDXHCI002 INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 1.0983 -0.00189
PDXHCI002 INK-128
0.001
mTORC1/2
PI3K/mTOR
 1.2910 -0.01484
PDXHCI002 INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 1.4120 -0.03534
PDXHCI002 INK-128
0.01
mTORC1/2
PI3K/mTOR
 1.3353 -0.05354
PDXHCI002 INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.8875 -0.05553
PDXHCI002 INK-128
0.1
mTORC1/2
PI3K/mTOR
 0.6193 -0.05362
PDXHCI002 INK-128
0.31623
mTORC1/2
PI3K/mTOR
 0.4597 -0.05379
PDXHCI002 INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.3512 -0.04857
PDXHCI002 INK-128
3.1623
mTORC1/2
PI3K/mTOR
 0.2290 -0.01288
PDXHCI002 PF-4708671
0.001
p70S6K
PI3K/mTOR
 1.0705 0.00745
PDXHCI002 PF-4708671
0.0031623
p70S6K
PI3K/mTOR
 1.0863 -0.00042
PDXHCI002 PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.0767 0.00058
PDXHCI002 PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0735 0.00089