Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| HCC1143 | Cediranib | 1.0 | VEGFR/cKIT | RTK | 0.8494 | 0.03666 |
| HCC1143 | Cediranib | 3.1623 | VEGFR/cKIT | RTK | 0.6007 | 0.05820 |
| HCC1143 | Cediranib | 10.0 | VEGFR/cKIT | RTK | 0.0093 | 0.13269 |
| HCC1143 | Cabozantinib | 0.001 | VEGFR2/MET | RTK | 0.9176 | -0.00021 |
| HCC1143 | Cabozantinib | 0.0031623 | VEGFR2/MET | RTK | 0.9455 | 0.00709 |
| HCC1143 | Cabozantinib | 0.01 | VEGFR2/MET | RTK | 0.9165 | 0.00445 |
| HCC1143 | Cabozantinib | 0.031623 | VEGFR2/MET | RTK | 0.9619 | -0.00150 |
| HCC1143 | Cabozantinib | 0.1 | VEGFR2/MET | RTK | 0.9406 | 0.00523 |
| HCC1143 | Cabozantinib | 0.31623 | VEGFR2/MET | RTK | 0.9166 | 0.00177 |
| HCC1143 | Cabozantinib | 1.0 | VEGFR2/MET | RTK | 0.9595 | 0.01326 |
| HCC1143 | Cabozantinib | 3.1623 | VEGFR2/MET | RTK | 0.8244 | 0.02275 |
| HCC1143 | Cabozantinib | 10.0 | VEGFR2/MET | RTK | 0.5122 | 0.08781 |
| PDXHCI002 | Abemaciclib | 0.001 | CDK4/6 | Cell cycle | 1.0814 | -0.01026 |
| PDXHCI002 | Abemaciclib | 0.0031623 | CDK4/6 | Cell cycle | 1.0168 | -0.02663 |
| PDXHCI002 | Abemaciclib | 0.01 | CDK4/6 | Cell cycle | 0.7972 | -0.03263 |
| PDXHCI002 | Abemaciclib | 0.031623 | CDK4/6 | Cell cycle | 0.5157 | -0.02723 |
| PDXHCI002 | Abemaciclib | 0.1 | CDK4/6 | Cell cycle | 0.2459 | -0.00392 |
| PDXHCI002 | Abemaciclib | 0.31623 | CDK4/6 | Cell cycle | 0.0127 | 0.02859 |
| PDXHCI002 | Abemaciclib | 1.0 | CDK4/6 | Cell cycle | -0.3115 | 0.16807 |
| PDXHCI002 | Abemaciclib | 3.1623 | CDK4/6 | Cell cycle | -0.5931 | 0.62133 |
| PDXHCI002 | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.6767 | 0.78021 |
| PDXHCI002 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 1.0643 | 0.00091 |
| PDXHCI002 | Palbociclib | 0.001 | CDK4/6 | Cell cycle | 1.0955 | 0.00139 |
| PDXHCI002 | Palbociclib | 0.0031623 | CDK4/6 | Cell cycle | 1.0235 | -0.01388 |
| PDXHCI002 | Palbociclib | 0.01 | CDK4/6 | Cell cycle | 0.9617 | -0.02387 |