Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
PDXHCI002 Palbociclib
0.031623
CDK4/6
Cell cycle
 0.7107 -0.01619
PDXHCI002 Palbociclib
0.1
CDK4/6
Cell cycle
 0.5498 -0.01504
PDXHCI002 Palbociclib
0.31623
CDK4/6
Cell cycle
 0.4357 -0.01897
PDXHCI002 Palbociclib
1.0
CDK4/6
Cell cycle
 0.3708 -0.01489
PDXHCI002 Palbociclib
3.1623
CDK4/6
Cell cycle
 0.2766 -0.00906
PDXHCI002 AZD7762
0.001
CHK1/2
Cell cycle
 1.1327 -0.00526
PDXHCI002 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.1211 -0.00033
PDXHCI002 AZD7762
0.01
CHK1/2
Cell cycle
 0.9155 0.00875
PDXHCI002 AZD7762
0.031623
CHK1/2
Cell cycle
 0.6236 0.05692
PDXHCI002 AZD7762
0.1
CHK1/2
Cell cycle
 0.3155 0.14437
PDXHCI002 AZD7762
0.31623
CHK1/2
Cell cycle
 0.0793 0.21527
PDXHCI002 AZD7762
1.0
CHK1/2
Cell cycle
 -0.3117 0.41043
PDXHCI002 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.5697 0.64335
PDXHCI002 AZD7762
10.0
CHK1/2
Cell cycle
 -0.5815 0.63902
PDXHCI002 Volasertib
0.0001
PLK
Cell cycle
 1.1077 -0.01282
PDXHCI002 Volasertib
0.00031623
PLK
Cell cycle
 1.1179 -0.00914
PDXHCI002 Volasertib
0.001
PLK
Cell cycle
 1.0918 0.00493
PDXHCI002 Volasertib
0.0031623
PLK
Cell cycle
 0.7068 0.08035
PDXHCI002 Volasertib
0.01
PLK
Cell cycle
 -0.4563 0.66284
PDXHCI002 Volasertib
0.031623
PLK
Cell cycle
 -0.4346 0.68960
PDXHCI002 Volasertib
0.1
PLK
Cell cycle
 -0.4496 0.68576
PDXHCI002 Volasertib
0.31623
PLK
Cell cycle
 -0.4807 0.69076
PDXHCI002 Volasertib
1.0
PLK
Cell cycle
 -0.5892 0.74035
PDXHCI002 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.1113 -0.00591
PDXHCI002 Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.1164 -0.00862